You Luling, Lin Yumeng, Zheng Yizhuo, Han Zhongyu, Zeng Liuzhi, Chen Haoran
School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Health Management Center, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, China.
Aging Dis. 2024 Oct 17. doi: 10.14336/AD.2024.0850.
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. Aging is an important risk factor for eye diseases. The gradual deterioration of ocular tissue structure and function with age leads to the onset and progression of ocular diseases. During aging, ocular tissues such as the lens, vitreous and retina are affected by age-related changes, such as oxidative stress and protein accumulation in the lens leading to cataract formation, and a decline in retinal pigment epithelial cell function associated with macular degeneration. This article reviews the relationships between aging and ocular diseases, takes age-related macular degeneration, age-related cataracts, glaucoma, diabetic retinal degeneration, and dry eye disease as focal points, analyses the complex interactions between aging and ocular diseases, and describes the therapeutic options and potential targets for age-related ocular diseases.
衰老的特征是生理完整性逐渐丧失，导致功能受损和死亡易感性增加。衰老是眼部疾病的一个重要风险因素。随着年龄增长，眼部组织结构和功能逐渐退化，导致眼部疾病的发生和发展。在衰老过程中，晶状体、玻璃体和视网膜等眼部组织会受到与年龄相关的变化影响，如晶状体中的氧化应激和蛋白质积累导致白内障形成，以及与黄斑变性相关的视网膜色素上皮细胞功能下降。本文综述了衰老与眼部疾病之间的关系，以年龄相关性黄斑变性、年龄相关性白内障、青光眼、糖尿病性视网膜病变和干眼症为重点，分析了衰老与眼部疾病之间的复杂相互作用，并描述了年龄相关性眼部疾病的治疗选择和潜在靶点。
