Institute for Translational Medicine, the Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao 266021, China.
Institute for Translational Medicine, the Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao 266021, China.
Life Sci. 2024 Aug 1;350:122769. doi: 10.1016/j.lfs.2024.122769. Epub 2024 Jun 6.
The forkhead box protein O3 (FOXO3a) belongs to the subgroup O of the forkhead transcription factor family and plays an important role in regulating the aging process by participating in the regulation of various life processes, including cell cycle arrest, apoptosis, autophagy, oxidative stress, and DNA repair. The eye is an organ that is affected by aging earlier. However, the functional role and potential clinical applications of FOXO3a in age-related eye diseases have not received widespread attention and lacked comprehensive and clear clarification. In this review, we demonstrated the relationship between FOXO3a and visual system health, summarized the functional roles of FOXO3a in various eye diseases, and potential ocular-related therapies and drugs targeting FOXO3a in visual system diseases through a review and summary of relevant literature. This review indicates that FOXO3a is an important factor in maintaining the normal function of various tissues in the eye, and is closely related to the occurrence and development of ophthalmic-related diseases. Based on its vital role in the normal function of the visual system, FOXO3a has potential clinical application value in related ophthalmic diseases. At present, multiple molecules and drugs targeting FOXO3a have been reported to have the potential for the treatment of related ophthalmic diseases, but further clinical trials are needed. In conclusion, this review can facilitate us to grasp the role of FOXO3a in the visual system and provide new views and bases for the treatment strategy research of age-related eye diseases.
叉头框蛋白 O3（FOXO3a）属于叉头转录因子家族 O 亚组，通过参与调节细胞周期停滞、细胞凋亡、自噬、氧化应激和 DNA 修复等各种生命过程，在调节衰老过程中发挥重要作用。眼睛是受衰老影响较早的器官。然而，FOXO3a 在与年龄相关的眼部疾病中的功能作用和潜在临床应用尚未受到广泛关注，缺乏全面和明确的澄清。在这篇综述中，我们通过回顾和总结相关文献，展示了 FOXO3a 与视觉系统健康之间的关系，总结了 FOXO3a 在各种眼部疾病中的功能作用，以及针对视觉系统疾病中 FOXO3a 的潜在眼部相关治疗方法和药物。这篇综述表明，FOXO3a 是维持眼部各种组织正常功能的重要因素，与眼部相关疾病的发生和发展密切相关。基于其在视觉系统正常功能中的重要作用，FOXO3a 在相关眼部疾病的治疗中有潜在的临床应用价值。目前，已有多种针对 FOXO3a 的分子和药物被报道具有治疗相关眼部疾病的潜力，但需要进一步的临床试验。总之，本综述可以帮助我们掌握 FOXO3a 在视觉系统中的作用，为与年龄相关的眼部疾病的治疗策略研究提供新的观点和依据。
