新型冠状病毒肺炎对大脑和心理健康的急性及长期影响：一项叙述性综述
Acute and long-term effects of COVID-19 on brain and mental health: A narrative review.
作者信息
Bremner J Douglas, Russo Scott J, Gallagher Richard, Simon Naomi M
机构信息
Departments of Psychiatry & Behavioral Sciences and Radiology, Emory University School of Medicine, Atlanta Georgia, and the Atlanta VA Medical Center, Decatur, GA, USA; Nash Family Department Neuroscience and Brain-Body Research Center, Icahn School of Medicine at Mt. Sinai, New York, NY, USA; Department of Child and Adolescent Psychiatry, New York University (NYU) Langone Health, New York, NY, USA.
Nash Family Department Neuroscience and Brain-Body Research Center, Icahn School of Medicine at Mt. Sinai, New York, NY, USA.
出版信息
Brain Behav Immun. 2025 Jan;123:928-945. doi: 10.1016/j.bbi.2024.11.007. Epub 2024 Nov 3.
BACKGROUND
COVID infection has been associated with long term sequalae (Long COVID) which include neurological and behavioral effects in thousands of patients, but the etiology and scope of symptoms is not well understood. This paper reviews long term sequelae of COVID on brain and mental health in patients with the Long COVID syndrome.
METHODS
This was a literature review which queried databases for Pubmed, Psychinfo, and Medline for the following topics for January 1, 2020-July 15, 2023: Long COVID, PASC, brain, brain imaging, neurological, neurobiology, mental health, anxiety, depression.
RESULTS
Tens of thousands of patients have developed Long COVID, with the most common neurobehavioral symptoms anosmia (loss of smell) and fatigue. Anxiety and mood disorders are elevated and seen in about 25% of Long COVID patients. Neuropsychological testing studies show a correlation between symptom severity and cognitive dysfunction, while brain imaging studies show global decreases in gray matter and alterations in olfactory and other brain areas.
CONCLUSIONS
Studies to date show an increase in neurobehavioral disturbances in patients with Long COVID. Future research is needed to determine mechanisms.
背景
新冠病毒感染与长期后遗症（新冠长期症状）有关，数千名患者出现了包括神经和行为方面的影响，但症状的病因和范围尚未完全明确。本文综述了新冠长期症状综合征患者新冠病毒感染对大脑和心理健康的长期影响。
方法
这是一项文献综述，于2020年1月1日至2023年7月15日在PubMed、Psychinfo和Medline数据库中查询以下主题：新冠长期症状、新冠后急性后遗症、大脑、脑成像、神经学、神经生物学、心理健康、焦虑、抑郁。
结果
数以万计的患者出现了新冠长期症状，最常见的神经行为症状是嗅觉丧失和疲劳。焦虑和情绪障碍有所增加，约25%的新冠长期症状患者出现此类症状。神经心理学测试研究表明症状严重程度与认知功能障碍之间存在关联，而脑成像研究显示灰质整体减少以及嗅觉和其他脑区发生改变。
结论
迄今为止的研究表明，新冠长期症状患者的神经行为障碍有所增加。需要进一步的研究来确定其机制。
Zotero 插件