在支气管肺发育不良婴儿中，速尿与氢氯噻嗪暴露与血清钠、钾和氯的关联。
Association of furosemide versus chlorothiazide exposures with serum sodium, potassium, and chloride among infants with bronchopulmonary dysplasia.
作者信息
Nelin Timothy D, Huber Matthew, Jensen Erik A, DeMauro Sara B, Morris Heidi, Lorch Scott A, Gibbs Kathleen, Alexiou Stamatia, Napolitano Natalie, Bustin Anna, Bamat Nicolas A
机构信息
Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
出版信息
J Perinatol. 2025 Mar;45(3):312-318. doi: 10.1038/s41372-024-02159-z. Epub 2024 Nov 5.
OBJECTIVES
To examine the association of novel furosemide versus thiazide diuretic exposure with changes in serum sodium, potassium, and chloride levels among infants with grade 2/3 bronchopulmonary dysplasia (BPD).
STUDY DESIGN
Retrospective cohort study of infants admitted to a level IV neonatal intensive care unit (NICU) with grade 2/3 BPD. We measured within-subject change in serum sodium, potassium, and chloride before and after diuretic initiation using multivariable regression to adjust for differences in dosing and clinical covariates.
RESULTS
We identified 94 infants contributing 137 novel diuretic exposures. No significant difference was noted in the association between chlorothiazide versus furosemide and serum sodium, potassium, or chloride change in multivariable modeling.
CONCLUSIONS
Changes in serum electrolytes were similar for chlorothiazide and furosemide, questioning the perception that chlorothiazide leads to less electrolyte derangement among preterm infants with grade 2/3 BPD.
目的
探讨新型速尿与噻嗪类利尿剂暴露与2/3级支气管肺发育不良（BPD）婴儿血清钠、钾和氯水平变化之间的关联。
研究设计
对入住四级新生儿重症监护病房（NICU）的2/3级BPD婴儿进行回顾性队列研究。我们使用多变量回归来调整剂量和临床协变量的差异，测量利尿剂开始使用前后血清钠、钾和氯的个体内变化。
结果
我们确定了94名婴儿，共进行了137次新型利尿剂暴露。在多变量模型中，氯噻嗪与速尿和血清钠、钾或氯变化之间的关联未发现显著差异。
结论
氯噻嗪和速尿引起的血清电解质变化相似，这对认为氯噻嗪导致2/3级BPD早产儿电解质紊乱较少的观点提出了质疑。
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