Iwaya Chihiro, Iwata Junichi
Department of Diagnostic & Biomedical Sciences, The University of Texas Health Science Center at Houston (UTHealth), School of Dentistry, Houston, Texas 77054, USA.
Center for Craniofacial Research, The University of Texas Health Science Center at Houston, School of Dentistry, Houston, TX 77054, USA.
Jpn Dent Sci Rev. 2024 Dec;60:232-238. doi: 10.1016/j.jdsr.2024.06.002. Epub 2024 Oct 21.
Sjögren's disease (SjD) is a systemic autoimmune disorder characterized by dry eyes and mouth caused by chronic inflammation and is often accompanied by various extra-glandular manifestations, including fatigue and diffuse pain. Although the pathogenesis of the disease remains elusive, several factors (e.g. environmental, genetic and hormonal factors, abnormal metabolic status) are associated with this condition. Accumulating evidence suggests a potential role of cholesterol metabolism in immune and non-immune modulation in various diseases. In this review, we summarize the current findings on the associations between cholesterol metabolism and SjD.
干燥综合征（SjD）是一种全身性自身免疫性疾病，其特征为慢性炎症导致的眼干和口干，常伴有多种腺外表现，包括疲劳和弥漫性疼痛。尽管该疾病的发病机制仍不清楚，但一些因素（如环境、遗传和激素因素、异常代谢状态）与这种情况有关。越来越多的证据表明胆固醇代谢在各种疾病的免疫和非免疫调节中具有潜在作用。在本综述中，我们总结了目前关于胆固醇代谢与干燥综合征之间关联的研究结果。
