地西司他：一种用于治疗慢性肾脏病所致贫血的新型脯氨酰羟化酶抑制剂。
Desidustat: a novel PHD inhibitor for the treatment of CKD-induced anemia.
作者信息
Joharapurkar Amit, Pandya Vrajesh, Patel Harilal, Jain Mukul, Desai Ranjit
机构信息
Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, Gujarat, India.
出版信息
Front Nephrol. 2024 Oct 22;4:1459425. doi: 10.3389/fneph.2024.1459425. eCollection 2024.
Abstract
Desidustat is a small molecule inhibitor of hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) discovered and developed by Zydus Lifesciences for the treatment of anemia associated with chronic kidney disease (CKD). This review summarizes the preclinical and clinical profile of desidustat which led to its approval and clinical use in India.
摘要
地西司他是一种小分子低氧诱导因子脯氨酰羟化酶（HIF-PH）抑制剂，由Zydus生命科学公司发现并开发，用于治疗与慢性肾脏病（CKD）相关的贫血。本综述总结了地西司他的临床前和临床概况，这些概况促成了其在印度的获批和临床应用。
Zotero 插件