Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, Guangdong, China.
Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, Guangdong, China.
Front Immunol. 2024 Oct 22;15:1442095. doi: 10.3389/fimmu.2024.1442095. eCollection 2024.
The mammalian gastrointestinal tract quickly becomes densely populated with foreign microorganisms shortly after birth, thereby establishing a lifelong presence of a microbial community. These commensal gut microbiota serve various functions, such as providing nutrients, processing ingested compounds, maintaining gut homeostasis, and shaping the intestinal structure in the host. Dysbiosis, which is characterized by an imbalance in the microbial community, is closely linked to numerous human ailments and has recently emerged as a key factor in health prognosis. Tuberculosis (TB), a highly contagious and potentially fatal disease, presents a pressing need for improved methods of prevention, diagnosis, and treatment strategies. Thus, we aim to explore the latest developments on how the host's immune defenses, inflammatory responses, metabolic pathways, and nutritional status collectively impact the host's susceptibility to or resilience against infection. The review addresses how the fluctuations in the gut microbiota not only affect the equilibrium of these physiological processes but also indirectly influence the host's capacity to resist . This work highlights the central role of the gut microbiota in the host-microbe interactions and provides novel insights for the advancement of preventative and therapeutic approaches against tuberculosis.
哺乳动物的胃肠道在出生后不久就会迅速被大量的外来微生物定植，从而建立起终生存在的微生物群落。这些共生的肠道微生物群具有多种功能，如提供营养、处理摄入的化合物、维持肠道内环境稳定以及塑造宿主的肠道结构。微生态失调是指微生物群落的失衡，它与许多人类疾病密切相关，并且最近已成为健康预后的关键因素。结核病（TB）是一种高度传染性且可能致命的疾病，迫切需要改进预防、诊断和治疗策略。因此，我们旨在探讨宿主的免疫防御、炎症反应、代谢途径和营养状况如何共同影响宿主对感染的易感性或抵抗力的最新研究进展。本综述探讨了肠道微生物群的波动如何不仅影响这些生理过程的平衡，还间接影响宿主的抵抗能力。这项工作强调了肠道微生物群在宿主-微生物相互作用中的核心作用，并为预防和治疗结核病提供了新的见解。
