• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

伴骨化生的TFE3重排肾细胞癌：1例具有罕见异常表现的罕见病例报告

TFE3-Rearranged Renal Cell Carcinoma With Osseous Metaplasia: A Case Report of a Rare Entity With an Unusual Finding.

作者信息

Bokhari Raghad A, Al-Zughbi Ali S, Bokhari Ziyad A

机构信息

Pathology and Laboratory Medicine, King Fahad Medical City, Riyadh, SAU.

Pathology and Laboratory Medicine, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Riyadh, SAU.

出版信息

Cureus. 2024 Nov 5;16(11):e73072. doi: 10.7759/cureus.73072. eCollection 2024 Nov.

DOI:10.7759/cureus.73072
PMID:39502747
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11537417/
Abstract

-rearranged renal cell carcinoma (RCC) is a rare subtype of renal tumor that typically affects the pediatric age group. Previous exposure to chemotherapy agents increases the possibility of having this subtype. Morphologically, it displays a broad spectrum of growth patterns, but it can be distinguished by the presence of melanin pigment or psammoma bodies. Osseous metaplasia is an uncommon morphological finding in this particular subtype, and it has been reported in two cases in the literature. We describe the third case of -rearranged renal cell carcinoma with osseous metaplasia in a healthy 13-year-old male, presenting with worsening abdominal pain and hematuria.

摘要

重排性肾细胞癌（RCC）是一种罕见的肾肿瘤亚型，通常影响儿童年龄组。既往接触化疗药物会增加患此亚型的可能性。在形态学上，它表现出广泛的生长模式，但可通过黑色素沉着或砂粒体的存在来鉴别。骨化生在这种特殊亚型中是一种不常见的形态学表现，文献中已有两例报道。我们描述了第三例重排性肾细胞癌合并骨化生的病例，患者为一名13岁健康男性，表现为腹痛加重和血尿。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4648/11537417/ce34c02bcb28/cureus-0016-00000073072-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4648/11537417/9d4aff2079e3/cureus-0016-00000073072-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4648/11537417/31820cb47502/cureus-0016-00000073072-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4648/11537417/ce34c02bcb28/cureus-0016-00000073072-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4648/11537417/9d4aff2079e3/cureus-0016-00000073072-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4648/11537417/31820cb47502/cureus-0016-00000073072-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4648/11537417/ce34c02bcb28/cureus-0016-00000073072-i03.jpg

相似文献

1
TFE3-Rearranged Renal Cell Carcinoma With Osseous Metaplasia: A Case Report of a Rare Entity With an Unusual Finding.伴骨化生的TFE3重排肾细胞癌：1例具有罕见异常表现的罕见病例报告
Cureus. 2024 Nov 5;16(11):e73072. doi: 10.7759/cureus.73072. eCollection 2024 Nov.
2
TFE3-rearranged RCC with osseous metaplasia found on bone mass densitometry.骨密度测定发现伴有骨化生的TFE3重排性肾细胞癌。
Ann Med Surg (Lond). 2024 Aug 14;86(10):6198-6202. doi: 10.1097/MS9.0000000000002479. eCollection 2024 Oct.
3
-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour.伴有骨化生及惰性生物学行为的重排性肾细胞癌
Urol Case Rep. 2022 Feb 25;42:102041. doi: 10.1016/j.eucr.2022.102041. eCollection 2022 May.
4
Diagnostic pitfall on the histological spectrum of adult-onset renal carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.与Xp11.2易位/TFE3基因融合相关的成人肾癌组织学谱系中的诊断陷阱。
Med Mol Morphol. 2010 Jun;43(2):86-90. doi: 10.1007/s00795-008-0423-x. Epub 2010 Aug 4.
5
Translocation carcinomas of the kidney.肾转移癌。
Genes Chromosomes Cancer. 2022 May;61(5):219-227. doi: 10.1002/gcc.23007. Epub 2021 Nov 3.
6
TFE3 break-apart FISH has a higher sensitivity for Xp11.2 translocation-associated renal cell carcinoma compared with TFE3 or cathepsin K immunohistochemical staining alone: expanding the morphologic spectrum.TFE3 断裂分离 FISH 检测与 TFE3 或组织蛋白酶 K 免疫组化染色单独检测相比，对 Xp11.2 易位相关性肾细胞癌具有更高的敏感性：扩大形态学谱。
Am J Surg Pathol. 2013 Jun;37(6):804-15. doi: 10.1097/PAS.0b013e31827e17cb.
7
Exploration of clinicopathological features of rearranged renal cell carcinoma and TFE3, TFEB, and ALK staining performance in renal entities.重排性肾细胞癌的临床病理特征及TFE3、TFEB和ALK在肾脏实体中的染色表现探索。
Heliyon. 2023 Apr 3;9(4):e15159. doi: 10.1016/j.heliyon.2023.e15159. eCollection 2023 Apr.
8
MiT family translocation renal cell carcinoma in an elderly male.老年男性的 MiT 家族易位相关性肾细胞癌。
Indian J Pathol Microbiol. 2021 Jul-Sep;64(3):553-555. doi: 10.4103/IJPM.IJPM_365_20.
9
TFE3 gene rearrangement and protein expression contribute to a poor prognosis of renal cell carcinoma.TFE3基因重排和蛋白表达导致肾细胞癌预后不良。
Heliyon. 2023 May 6;9(5):e16076. doi: 10.1016/j.heliyon.2023.e16076. eCollection 2023 May.
10
A novel VCP::TFE3 gene fusion resulting from t(X;9)(p11.23;p13.3) chromosome translocation in TFE3 rearranged renal cancer cell carcinoma.在TFE3重排的肾细胞癌中，由t(X;9)(p11.23;p13.3)染色体易位产生的一种新型VCP::TFE3基因融合。
Genes Chromosomes Cancer. 2023 Jun;62(6):361-366. doi: 10.1002/gcc.23127. Epub 2023 Feb 13.

本文引用的文献

1
Re: WHO Classification of Tumours, 5th Edition, Volume 8: Urinary and Male Genital Tumours.关于：《世界卫生组织肿瘤分类》第5版，第8卷：泌尿系统和男性生殖系统肿瘤。
Eur Urol. 2023 Sep;84(3):348-349. doi: 10.1016/j.eururo.2023.04.030. Epub 2023 May 10.
2
-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour.伴有骨化生及惰性生物学行为的重排性肾细胞癌
Urol Case Rep. 2022 Feb 25;42:102041. doi: 10.1016/j.eucr.2022.102041. eCollection 2022 May.
3
Renal cell carcinoma in children and adolescents: Single-center experience and literature review.
儿童和青少年肾细胞癌：单中心经验和文献回顾。
Medicine (Baltimore). 2021 Jan 15;100(2):e23717. doi: 10.1097/MD.0000000000023717.