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子宫腺肌病发生相关因素及子宫腺肌病与乳腺癌之间联系的回顾性研究。

Retrospective study of the factors involved in the development of adenomyosis and the link between adenomyosis and breast cancer.

作者信息

Borozan Florina, Semenescu Alexandra Denisa, Sas Ioan, Bernad Elena, Iftode Andrada, Iftode Claudia, Susan Monica, Radu Daniela

机构信息

Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, Timişoara, Romania.

Research Centre for Pharmaco-Toxicological Evaluation, Victor Babes University of Medicine and Pharmacy, Timişoara, Romania.

出版信息

Med Pharm Rep. 2024 Oct;97(4):477-487. doi: 10.15386/mpr-2747. Epub 2024 Oct 30.

DOI:10.15386/mpr-2747
PMID:39502755
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11534385/
Abstract

BACKGROUND AND AIMS

Adenomyosis is a heterogeneous disease, which differs from patient to patient. The objective of our study was to evaluate the risk factors that influence the occurrence of adenomyosis, more precisely to highlight aspects that may be used in practice. In addition, the impact of levonorgestrel (a possible predisposing factor in the occurrence of adenomyosis) on MDA-MB-231 cells was evaluated, trying to obtain a link between adenomyosis and mammary cancer.

METHODS

Clinical and demographic data of patients diagnosed with adenomyosis hospitalized between January and September 2023 in the Obstetrics-Gynecology Clinic were analyzed. For the assays, the MTT and LDH method was used to investigate the effect on cell viability and the potential cytotoxic effect of LG on MDA-MB-23 cells.

RESULTS

Out of a total of 99 hysterectomies performed, the diagnosis of adenomyosis was confirmed by ultrasound in 28 cases. Among our patients, we could observe that most of cases of adenomyosis developed in women between 40 and 45 years old. Multiple pregnancies can influence the development of this uterine pathology, along with a history of uterine surgery and abortions. It was also found that treatment with sex hormones can increase the risk of adenomyosis. Our study has showed that LG stimulates the proliferation of MDA-MB-231 cells depending on the dose and time.

CONCLUSIONS

Personal history along with progestin treatment may influence myometrial lesions, leading to diffuse or focal adenomyosis. Moreover, , LG has been shown to stimulate the proliferation of breast cancer cells.

摘要

背景与目的

子宫腺肌病是一种异质性疾病，患者之间存在差异。我们研究的目的是评估影响子宫腺肌病发生的危险因素，更确切地说是突出在实践中可能有用的方面。此外，评估了左炔诺孕酮（子宫腺肌病发生的一个可能诱发因素）对MDA - MB - 231细胞的影响，试图建立子宫腺肌病与乳腺癌之间的联系。

方法

分析了2023年1月至9月在妇产科诊所住院的诊断为子宫腺肌病患者的临床和人口统计学数据。对于实验，采用MTT和LDH方法研究左炔诺孕酮对细胞活力的影响以及对MDA - MB - 23细胞的潜在细胞毒性作用。

结果

在总共进行的99例子宫切除术中，超声确诊子宫腺肌病28例。在我们的患者中，我们可以观察到大多数子宫腺肌病病例发生在40至45岁的女性中。多次妊娠、子宫手术史和流产史会影响这种子宫疾病的发生。还发现性激素治疗会增加子宫腺肌病的风险。我们的研究表明，左炔诺孕酮根据剂量和时间刺激MDA - MB - 231细胞的增殖。

结论

个人病史以及孕激素治疗可能影响子宫肌层病变，导致弥漫性或局灶性子宫腺肌病。此外，已表明左炔诺孕酮会刺激乳腺癌细胞的增殖。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf5/11534385/fd190547b94d/cm-97-477f7.jpg
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Adenomyosis and Its Possible Malignancy: A Review of the Literature.子宫腺肌病及其潜在恶性变：文献综述
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