Fotakopoulos George, Gatos Charalabos, Georgakopoulou Vasiliki E, Christodoulidis Grigorios, Kagkouras Iraklis, Trakas Nikolaos, Foroglou Nikolaos
Neurosurgery, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Neurosurgery, General University Hospital of Larissa, Larissa, GRC.
Cureus. 2024 Oct 6;16(10):e70946. doi: 10.7759/cureus.70946. eCollection 2024 Oct.
This study investigated the association of sigma receptors (SRs) and their selective ligands (because the molecular characteristics of the same SRs, particularly sigma-2 receptor {S2R}, are not completely clear) in carcinogenesis, their potential use as antitumor agents, and their great utility in tumor imaging. The ion channels and transporters enhance the cell's ability to adapt to the metabolic conditions encountered in the tumor tissue. The high expression of SRs in the proliferating cells compared with those at rest indicates that this is a significant clinical biomarker for determining the proliferative status of solid tumors using functional PET imaging techniques. The association of SRs in the pathophysiology of cancer cells is a result of the high concentration of S1R and S2R binding sites observed in various tumor cell lines and tissues. It would also be remarkable to determine if SRs are involved in metastasis and other metastatic cell behaviors such as adhesion, secretion, motility, and penetration. An absolute challenge for research in this field is to develop an integrated model that describes the molecular mechanisms of sigma receptors, incorporating their known biological and pathophysiological roles.
本研究调查了σ受体（SRs）及其选择性配体（因为相同SRs的分子特征，尤其是σ-2受体{S2R}，尚不完全清楚）在致癌过程中的关联、它们作为抗肿瘤药物的潜在用途以及在肿瘤成像中的巨大效用。离子通道和转运体增强了细胞适应肿瘤组织中代谢条件的能力。与静止细胞相比，增殖细胞中SRs的高表达表明，这是使用功能性PET成像技术确定实体瘤增殖状态的一个重要临床生物标志物。SRs在癌细胞病理生理学中的关联是在各种肿瘤细胞系和组织中观察到高浓度S1R和S2R结合位点的结果。确定SRs是否参与转移以及其他转移细胞行为，如黏附、分泌、运动和侵袭，也将是值得关注的。该领域研究的一个绝对挑战是开发一个综合模型，描述σ受体的分子机制，并纳入其已知的生物学和病理生理学作用。
