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高压氧治疗颌骨药物相关性骨坏死的管理:一例报告

Management of Medication-Related Osteonecrosis of the Jaws With Hyperbaric Oxygen Therapy: A Case Report.

作者信息

Anand Rakshak, Kumar Yajas, Bhagat Nitin, Chakarvarty Kapila, Jaiswal Yashmi

机构信息

Department of Oral and Maxillofacial Surgery, Manav Rachna Dental College, Faridabad, IND.

Oral and Maxillofacial Surgery, Private Practice, New Delhi, IND.

出版信息

Cureus. 2024 Oct 6;16(10):e70940. doi: 10.7759/cureus.70940. eCollection 2024 Oct.

Abstract

Medication-related osteonecrosis of the jaw (MRONJ) refers to the condition where the maxillary or mandibular bone becomes exposed and necrotic as a result of bisphosphonate therapy. The number of patients on bisphosphonates is increasing and so are the MRONJ cases. Since the initial data were published in the early 2000s, research into MRONJ has expanded significantly to enhance the understanding of this emerging condition. Various treatment options are available, but none have been established as the definitive "gold standard" for managing this disease. Hyperbaric oxygen therapy (HOT) is one of the treatment modalities for MRONJ, which has generated successful outcomes and an improvement in the quality of life along with a reduction in morbidity, as mentioned in the literature. We validate this by reporting a case of MRONJ successfully treated with HOT.

摘要

药物相关性颌骨坏死(MRONJ)是指由于双膦酸盐治疗导致上颌骨或下颌骨暴露并坏死的情况。使用双膦酸盐的患者数量在增加,MRONJ病例也在增多。自21世纪初首次发表相关数据以来,对MRONJ的研究已大幅扩展,以增进对这种新出现病症的了解。有多种治疗选择,但尚无一种被确立为治疗该疾病的 definitive “金标准”。高压氧治疗(HOT)是MRONJ的治疗方式之一,如文献所述,它已产生了成功的治疗效果,提高了生活质量并降低了发病率。我们通过报告一例成功接受HOT治疗的MRONJ病例来证实这一点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a84/11537256/0d457957b967/cureus-0016-00000070940-i01.jpg

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