Ensing Amy E, Getahun Henok, Lin Rebecca Z, Zhang Amy L, Landes Emma K, Lieu Judith E C
Department of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, U.S.A.
Laryngoscope. 2025 Apr;135(4):1525-1531. doi: 10.1002/lary.31893. Epub 2024 Nov 6.
To investigate the relationship between pediatric obstructive sleep apnea (OSA) severity and quality of life (QOL).
This study was a cross-sectional survey.
Patients aged 2-18 years being evaluated for OSA were recruited from a pediatric otolaryngology clinic and sleep center. Participants completed the Obstructive Sleep Apnea Questionnaire (OSA-18) and the PedsQL™ Multidimensional Fatigue Score (MFS).
Responses of 18 control participants without OSA, 26 participants with clinically resolved OSA, 19 with non-obstructive sleep disordered breathing (SDB), 29 with mild OSA, 21 with moderate OSA, and 27 with severe OSA were analyzed. OSA-18 scores for controls were lower (indicating higher QOL) than patients with SDB (mean difference [MD] = -31.1; 95% CI -42.7 to -19.5), mild OSA (MD = -30.4; 95% CI -40.1 to -20.7), moderate OSA (MD = -23.6; 95% CI -34.5 to -12.7), or severe OSA (MD = -40.1; 95% CI -50.0 to -30.2). Participants with resolved OSA also had lower OSA-18 scores than participants in the SDB and OSA groups. Few differences were observed between the SDB, mild OSA, moderate OSA, and severe OSA groups on either the OSA-18 or PedsQL MFS, and these did not demonstrate a clear pattern. Linear regression of apnea hypopnea index (AHI) and OSA-18 or PedsQL MFS scores revealed weak relationships (R < 0.1).
Using both an OSA-specific measure and generic fatigue measure, no consistent differences in QOL scores were found between children with varying OSA severities. Therefore, disease burden in pediatric patients with mild OSA and SDB should not be underestimated.
3 Laryngoscope, 135:1525-1531, 2025.
探讨小儿阻塞性睡眠呼吸暂停（OSA）严重程度与生活质量（QOL）之间的关系。
本研究为横断面调查。
从儿科耳鼻喉科诊所和睡眠中心招募年龄在2至18岁、正在接受OSA评估的患者。参与者完成了阻塞性睡眠呼吸暂停问卷（OSA - 18）和儿童生活质量量表（PedsQL™）多维疲劳评分（MFS）。
分析了18名无OSA的对照参与者、26名临床治愈的OSA参与者、19名非阻塞性睡眠呼吸障碍（SDB）参与者、29名轻度OSA参与者、21名中度OSA参与者和27名重度OSA参与者的回答。对照组的OSA - 18评分低于SDB患者（表明生活质量更高）（平均差异[MD]= - 31.1；95%可信区间 - 42.7至 - 19.5）、轻度OSA患者（MD = - 30.4；95%可信区间 - 40.1至 - 20.7）、中度OSA患者（MD = - 23.6；95%可信区间 - 34.5至 - 12.7）或重度OSA患者（MD = - 40.1；95%可信区间 - 50.0至 - 30.2）。已治愈OSA的参与者的OSA - 18评分也低于SDB组和OSA组的参与者。在OSA - 18或PedsQL MFS上，SDB组、轻度OSA组、中度OSA组和重度OSA组之间几乎没有观察到差异，且这些差异未呈现出明显的模式。呼吸暂停低通气指数（AHI）与OSA - 18或PedsQL MFS评分的线性回归显示相关性较弱（R < 0.1）。
使用OSA特异性测量方法和一般疲劳测量方法，未发现不同OSA严重程度的儿童在生活质量评分上存在一致差异。因此，轻度OSA和SDB小儿患者的疾病负担不应被低估。
3《喉镜》，135:1525 - 1531，2025年。
