Laliberté Alexandra, Siafa Lyna, Soufi Arij, Dassi Christelle, Russ-Hall Sophie J, Scheffer Ingrid E, Myers Kenneth A
Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada.
Research Institute of the McGill University Medical Centre, Montreal, Quebec, Canada.
Epilepsia. 2025 Jan;66(1):e1-e6. doi: 10.1111/epi.18179. Epub 2024 Nov 6.
This study evaluated food preferences and eating behaviors of individuals with Dravet syndrome. Patients diagnosed with Dravet syndrome were recruited, as well as a control group composed of siblings of patients with epilepsy (any form). The Food Preference Questionnaire and the Child Eating Behavior Questionnaire were completed by caregivers along with two open-ended questions regarding eating challenges. Seventy-eight participants (45 with Dravet syndrome and 33 controls) were included. Compared to controls, mean scores for food preference were lower for fruits (p = .000099), meats and fish (p = .00094), and snacks (p = .000027) in Dravet syndrome. People with Dravet syndrome also had less emotional overeating (p = .0085) and food enjoyment (p = .0012), but more slowness in eating (p = .00021) and food fussiness (p = .0064). In a subgroup analysis of only pediatric (age <18 years) patients, similar results were observed for both food preferences and eating habits. In qualitative data, caregivers most commonly reported difficulties with fixation on specific foods. This study demonstrates specific food preferences and challenging eating behaviors in individuals with Dravet syndrome. These data provide potential avenues for nutritional interventions and behavioral therapies to increase the quality of life of patients and their families.
本研究评估了患有德雷维特综合征个体的食物偏好和饮食行为。招募了被诊断为德雷维特综合征的患者,以及一个由癫痫患者(任何形式)的兄弟姐妹组成的对照组。照顾者完成了食物偏好问卷和儿童饮食行为问卷,以及两个关于饮食挑战的开放式问题。共纳入78名参与者(45名患有德雷维特综合征,33名对照)。与对照组相比,德雷维特综合征患者在水果(p = 0.000099)、肉类和鱼类(p = 0.00094)以及零食(p = 0.000027)方面的食物偏好平均得分较低。患有德雷维特综合征的人情绪性暴饮暴食(p = 0.0085)和食物享受感(p = 0.0012)也较低,但进食速度较慢(p = 0.00021)且挑食(p = 0.0064)。在仅针对儿科(年龄<18岁)患者的亚组分析中,在食物偏好和饮食习惯方面观察到了类似的结果。在定性数据中,照顾者最常报告的困难是对特定食物的执着。本研究证明了德雷维特综合征患者存在特定的食物偏好和具有挑战性的饮食行为。这些数据为营养干预和行为疗法提供了潜在途径,以提高患者及其家庭的生活质量。