Karhunen P J, Penttilä A, Liesto K, Männikkö A, Möttönen M
J Hepatol. 1986;2(1):89-99. doi: 10.1016/s0168-8278(86)80012-5.
Pathogenetic associations between benign hepatic tumours and liver damage were studied in an autopsy series of 91 males with high incidence of alcoholism. Information on the consumption of alcohol was obtained by interviewing a family member or a close friend of the deceased. The reported use of alcohol correlated well with the increase of fatty and fibrotic changes and with the occurrence of liver cirrhosis, alcoholic hepatitis or pancreatitis. Benign bile duct tumours (bile duct adenomas and von Meyenburg's complexes) (n = 26) were associated with the occurrence of bridging (P less than 0.0005) and periportal (P less than 0.025) fibrosis of the liver and, independently from these, with chronic pancreatitis (P less than 0.05) and with non-parasitic liver cysts (n = 14) (P less than 0.01). The weight of the liver was greater (P less than 0.01) in males with focal nodular hyperplasia (n = 3). Cavernous hemangioma (n = 19) occurred independently of the parameters studied. None of the tumours showed significant correlation to liver cirrhosis, alcoholic hepatitis, fatty liver or diseases of the gallbladder. The results are in line with observations on the reactive nature and connections to fibropolycystic liver disease of benign bile duct tumours in laboratory animals and in man. Their presence in human liver specimens should be taken into account as a sign of liver damage, in this study related to heavy use of alcohol or to chronic inflammation of the pancreas.
在一个有91名男性的尸检系列中研究了良性肝肿瘤与肝损伤之间的发病机制关联，这些男性酗酒发生率高。通过采访死者的家庭成员或密友获得饮酒信息。报告的饮酒情况与脂肪变性和纤维化改变的增加以及肝硬化、酒精性肝炎或胰腺炎的发生密切相关。良性胆管肿瘤（胆管腺瘤和梅耶堡复合体）（n = 26）与肝桥接纤维化（P < 0.0005）和门周纤维化（P < 0.025）的发生相关，且独立于这些情况，还与慢性胰腺炎（P < 0.05）和非寄生虫性肝囊肿（n = 14）（P < 0.01）相关。局灶性结节性增生患者（n = 3）的肝脏重量更大（P < 0.01）。海绵状血管瘤（n = 19）的发生与所研究的参数无关。没有一种肿瘤与肝硬化、酒精性肝炎、脂肪肝或胆囊疾病有显著相关性。这些结果与在实验动物和人类中对良性胆管肿瘤的反应性本质及其与纤维多囊肝病的联系的观察结果一致。在本研究中，考虑到与大量饮酒或胰腺慢性炎症相关，它们在人类肝脏标本中的存在应被视为肝损伤的一个迹象。
