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肥胖相关性猝死:机制与管理。

Sudden Death in Obesity: Mechanisms and Management.

机构信息

Center for Cardiac Arrest Prevention, Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.

出版信息

J Am Coll Cardiol. 2024 Dec 3;84(23):2308-2324. doi: 10.1016/j.jacc.2024.09.016. Epub 2024 Nov 6.

Abstract

In recent decades, the prevalence of obesity has increased significantly, leading to an epidemic at the global level. Obesity is associated with various metabolic alterations and increases the risk of cardiovascular disease. The most devastating manifestation of cardiovascular disease is sudden cardiac death (SCD), leading to substantial years of potential life lost worldwide. Obesity-related SCD is an increasingly important public health problem and warrants a specific investigative focus on improved risk stratification and prevention. In this review, we summarize the current evidence regarding management of SCD in obesity and discuss knowledge gaps as well as future directions in this field.

摘要

近几十年来,肥胖症的患病率显著增加,导致了在全球范围内的流行。肥胖与各种代谢改变有关,并增加了心血管疾病的风险。心血管疾病最具破坏性的表现是心源性猝死(SCD),导致全球大量潜在寿命的丧失。肥胖相关的心源性猝死是一个日益重要的公共卫生问题,需要特别关注改善风险分层和预防。在这篇综述中,我们总结了肥胖症中心源性猝死管理的现有证据,并讨论了这一领域的知识空白和未来方向。

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