Universidade Brasil, Rua Carolina Fonseca, 584, Itaquera, 08230-030 São Paulo, SP, Brazil.
Universidade Federal de São Paulo, Rua Silva Jardim, 136, Vila Mathias, 11015-020 Santos, SP, Brazil.
An Acad Bras Cienc. 2024 Nov 4;96(suppl 3):e20240402. doi: 10.1590/0001-3765202420240402. eCollection 2024.
Platelet rich plasma and ozone therapy have been suggested in the clinical setting as promising and adjuvant therapies for managing the symptoms related to the facial aging. However, there is a lack of evidence about the effects of combining both therapies on rejuvenation. Thus, the aim of the present study was to evaluate and to compare the safety and efficacy of both therapies in facial aging. A single-center prospective pilot study was conducted. Female participants, aged 40 to 60 years, were randomized into 2 groups: participants received the platelet rich plasma treatment (PRP); participants received the therapy with platelet rich plasma associated with ozone therapy (PRPOT). Interventions were performed using the facial intradermal technique in 42 pre-established points, for 4 sessions with an interval of 15 days between them. After analyses performed using photographic records, assessment of frontal, periorbital, nasolabial and marionette wrinkles (Wrinkle Assessment Scale), self-esteem assessment (Brazilian Version of Rosenberg's Self-Esteem Scale) and assessment of patient satisfaction (FACE-Q) can be suggested that the platelet rich plasma protocol performed in the present study, as well as its association with volume-controlled ozone therapy, proved to be safe and potentially promising modalities in the treatment of facial aging.
富血小板血浆和臭氧疗法已在临床中被提出，作为管理与面部衰老相关症状的有前途和辅助疗法。然而，关于两种疗法联合使用对面部年轻化的效果的证据不足。因此，本研究的目的是评估和比较这两种疗法对面部衰老的安全性和疗效。进行了一项单中心前瞻性试点研究。年龄在 40 至 60 岁之间的女性参与者被随机分为两组：一组接受富血小板血浆治疗（PRP）；另一组接受富血小板血浆联合臭氧疗法的治疗（PRPOT）。干预措施采用面部皮内技术在 42 个预先设定的点进行，每 15 天进行 4 次。通过对照片记录进行分析，可以评估额部、眶周、鼻唇沟和木偶纹皱纹（皱纹评估量表）、自尊评估（巴西版罗森伯格自尊量表）和患者满意度评估（FACE-Q），可以认为本研究中进行的富血小板血浆方案，以及其与容量控制臭氧疗法的联合应用，在治疗面部衰老方面是安全且有潜力的方法。
