Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia, 46010 Valencia, Spain.
Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia, 46010 Valencia, Spain; National Research Centre for the Working Environment, Copenhagen, Denmark.
Clin Nutr. 2024 Dec;43(12):218-224. doi: 10.1016/j.clnu.2024.10.022. Epub 2024 Oct 19.
BACKGROUND & AIMS: Questions remain whether higher handgrip strength confers additional health advantages beyond adherence to current physical activity guidelines. We aimed to evaluate prospective associations of joint objectively measured handgrip strength and physical activity with incident cardiovascular disease (CVD) and all-cause mortality.
We analysed the UK Biobank study in a cohort of participants who wore accelerometers for one week, with follow-up based on hospital records until 2022. Patterns of physical activity were compared: participants who met current moderate-vigorous physical activity guidelines (150 min per week) and those who did not. Handgrip strength was classified into sex- and age-specific tertiles. CVD events were identified as primary or secondary by examination of inpatient records and data extracted from the death registry. CVD-related deaths were also identified from the death registry. We examined prospective associations of moderate-vigorous physical activity with incident CVD and all-cause mortality by level of handgrip using Cox regressions, adjusted for confounding factors.
A total of 76 074 persons were included (mean 55.2 years). Meeting physical activity guidelines is necessary to reduce all-cause mortality in those at the lower and middle thirds of handgrip strength. However, meeting physical activity guidelines did not confer additional reduction of all-cause mortality of those with high handgrip strength. Those with the lowest handgrip strength showed the greatest benefit from meeting physical activity guidelines for reducing all-cause mortality (HR 0.74; 95 % CI 0.65-0.85).
Our results indicate that, while following physical activity guidelines does not reduce mortality in individuals with high handgrip strength, it is essential for preventing cardiovascular disease across all levels of handgrip strength. This underscores the importance of these guidelines for cardiovascular health.
目前仍存在疑问，即更高的握力是否除了遵循当前的体力活动指南之外，还能带来额外的健康益处。我们旨在评估联合使用客观测量的手部握力和体力活动与心血管疾病（CVD）和全因死亡率的前瞻性关联。
我们对 UK Biobank 研究中的参与者进行了分析，这些参与者佩戴了一周的加速度计，随访时间基于医院记录至 2022 年。比较了体力活动的模式：符合当前中等至剧烈体力活动指南（每周 150 分钟）的参与者和不符合指南的参与者。将握力分为性别和年龄特异性三分位数。通过检查住院记录和从死亡登记处提取的数据来确定 CVD 事件，作为原发性或继发性疾病。还从死亡登记处确定了与 CVD 相关的死亡。我们使用 Cox 回归分析了中等至剧烈体力活动与握力水平相关的 CVD 事件和全因死亡率的前瞻性关联，同时调整了混杂因素。
共有 76074 人被纳入（平均年龄 55.2 岁）。在握力处于中下三分之一的人群中，符合体力活动指南是降低全因死亡率的必要条件。然而，对于握力较高的人群，符合体力活动指南并不能进一步降低全因死亡率。握力最低的人群从符合体力活动指南中获益最大，可降低全因死亡率（HR 0.74；95%CI 0.65-0.85）。
我们的研究结果表明，虽然遵循体力活动指南并不能降低握力较高的个体的死亡率，但对于预防所有握力水平的心血管疾病至关重要。这突显了这些指南对心血管健康的重要性。
