Chen Stacey, Lee Erin C S, Napier Kelby B, Rainbow Michael J, Lawrence Rebekah L
Program in Physical Therapy, Washington University School of Medicine in St. Louis, 4444 Forest Park Avenue, St. Louis, MO, 63108, USA.
Department of Mechanical and Materials Engineering, Queen's University, McLaughlin Hall, 130 Stuart Street, Kingston, Ontario, Canada.
Ann Biomed Eng. 2025 Feb;53(2):481-491. doi: 10.1007/s10439-024-03645-3. Epub 2024 Nov 6.
Model-based tracking is being increasingly used to quantify shoulder kinematics and typically employs computed tomography (CT) to create the 3D bone volumes, which adds to the total radiation exposure. Lower-dose CT protocols may be possible given the contrast between bone and the surrounding soft tissues. The purpose of this study was to describe the dose-accuracy tradeoff between low-dose CT scans and the kinematic tracking accuracy of the humerus, scapula, and clavicle when tracked using an intensity-based registration algorithm.
Three fresh-frozen cadavers consisting of the torso and bilateral shoulders were tested. The CT protocols investigated included a full-dose protocol and 4 experimental low-dose protocols that modulated x-ray tube current and peak voltage. Bead-based tracking (i.e., radiostereometric analysis) served as the reference standard to which model-based tracking results were compared. Accuracy was described in terms of both segmental (humerus, scapula, and clavicle) and joint (glenohumeral, acromioclavicular) kinematics using root-mean-square (RMSE), bias, precision, and worst-case errors.
The low-dose CT scans resulted in an average dose reduction of 70.6-92.8%. RMSEs tended to increase as CT dose decreased with average glenohumeral errors increasing from 0.5° and 0.6 mm to 0.6° and 0.6 mm between the highest and lowest-dose protocols, and average acromioclavicular errors increasing from 0.6° and 0.8 mm to 0.7° and 0.9 mm. However, the difference in joint kinematic errors between the highest and lowest-dose CT scanning protocols was generally small (≤0.3°, ≤ 0.1 mm).
It is possible to substantially reduce the CT dose associated with shoulder motion analysis using biplane videoradiography without significantly impacting data fidelity.
基于模型的跟踪越来越多地用于量化肩部运动学,通常采用计算机断层扫描(CT)来创建三维骨体积,这会增加总的辐射暴露量。鉴于骨骼与周围软组织之间的对比度,低剂量CT方案可能是可行的。本研究的目的是描述低剂量CT扫描与使用基于强度的配准算法跟踪时肱骨、肩胛骨和锁骨的运动学跟踪准确性之间的剂量-准确性权衡。
对包含躯干和双侧肩部的三具新鲜冷冻尸体进行测试。研究的CT方案包括一个全剂量方案和4个实验性低剂量方案,这些方案调节了X射线管电流和峰值电压。基于珠的跟踪(即放射立体分析)作为参考标准,与基于模型的跟踪结果进行比较。使用均方根(RMSE)、偏差、精度和最坏情况误差,从节段(肱骨、肩胛骨和锁骨)和关节(盂肱关节、肩锁关节)运动学方面描述准确性。
低剂量CT扫描导致平均剂量降低70.6-92.8%。随着CT剂量降低,RMSE往往会增加,最高和最低剂量方案之间,平均盂肱关节误差从0.5°和0.6毫米增加到0.6°和0.6毫米,平均肩锁关节误差从0.6°和0.8毫米增加到0.7°和0.9毫米。然而,最高和最低剂量CT扫描方案之间的关节运动学误差差异通常较小(≤0.3°,≤0.1毫米)。
使用双平面视频放射摄影术可以大幅降低与肩部运动分析相关的CT剂量,而不会显著影响数据保真度。