Bray G A, Dahms W T, Atkinson R L, Rodin J, Taylor I, Frame C, Schwartz A
Horm Metab Res. 1979 Dec;11(12):648-54. doi: 10.1055/s-0028-1092792.
The present studies were designed to compare physiological and behavioral changes produced by weight loss induced with dieting and the weight loss which follows intestinal bypass. A group of 7 grossly obese individuals were hospitalized in a metabolic unit and studied at their initial weight after 4 weeks on a hypocaloric diet and again following a comparable weight loss after intestinal bypass surgery. The score indicating depression increased after dieting, but returned to initial levels after bypass. A number of other behavioral changes were recorded including a reduction in the time spent thinking about food, the time when the individual felt hungry and a greater percentage of time when they felt "full". After bypass, the patients also selected and ate smaller quantities of food. There were no metabolic differences following the period of dieting. Among the metabolic changes after bypass were an increase in glycerol and a decrease in insulin. The possible relationships between the metabolic and behavioral changes have been reviewed.
本研究旨在比较节食引起的体重减轻与肠道分流术后体重减轻所产生的生理和行为变化。一组7名严重肥胖个体入住代谢病房，在低热量饮食4周后按初始体重进行研究，并在肠道分流手术后体重出现类似减轻后再次进行研究。表明抑郁的评分在节食后增加，但在分流后恢复到初始水平。记录了许多其他行为变化，包括思考食物的时间减少、个体感到饥饿的时间以及感到“饱”的时间百分比增加。分流后，患者还选择并食用了较少量的食物。节食期间没有代谢差异。分流后的代谢变化包括甘油增加和胰岛素减少。已对代谢和行为变化之间的可能关系进行了综述。
