爱泼斯坦-巴尔病毒发现60周年的研究里程碑。

Research landmarks on the 60th anniversary of Epstein-Barr virus.

作者信息

Zhong Lan-Yi, Xie Chu, Zhang Le-Le, Yang Yan-Lin, Liu Yuan-Tao, Zhao Ge-Xin, Bu Guo-Long, Tian Xian-Shu, Jiang Zi-Ying, Yuan Bo-Yu, Li Peng-Lin, Wu Pei-Huang, Jia Wei-Hua, Münz Christian, Gewurz Benjamin E, Zhong Qian, Sun Cong, Zeng Mu-Sheng

机构信息

State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.

Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, 8092, Switzerland.

出版信息

Sci China Life Sci. 2025 Feb;68(2):354-380. doi: 10.1007/s11427-024-2766-0. Epub 2024 Nov 4.

DOI:10.1007/s11427-024-2766-0

PMID:39505801

Abstract

Epstein-Barr virus (EBV), the first human oncovirus discovered in 1964, has become a focal point in virology, immunology, and oncology because of its unique biological characteristics and significant role in human diseases. As we commemorate the 60th anniversary of EBV's discovery, it is an opportune moment to reflect on the major advancements in our understanding of this complex virus. In this review, we highlight key milestones in EBV research, including its virion structure and life cycle, interactions with the host immune system, association with EBV-associated diseases, and targeted intervention strategies.

摘要

爱泼斯坦-巴尔病毒（EBV）于1964年被发现，是首个被发现的人类肿瘤病毒。由于其独特的生物学特性以及在人类疾病中的重要作用，它已成为病毒学、免疫学和肿瘤学的焦点。在我们纪念EBV发现60周年之际，这是一个反思我们对这种复杂病毒理解上重大进展的恰当时机。在这篇综述中，我们重点介绍EBV研究中的关键里程碑，包括其病毒粒子结构和生命周期、与宿主免疫系统的相互作用、与EBV相关疾病的关联以及靶向干预策略。