Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
University of Ottawa Brain and Mind Research Institute, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
Transl Psychiatry. 2024 Nov 6;14(1):462. doi: 10.1038/s41398-024-03168-4.
The ephrin receptors (EphRs) are the largest family of receptor tyrosine kinases (RTKs) that are abundantly expressed in the developing brain and play important roles at different stages of neurogenesis ranging from neural stem cell (NSC) fate specification to neural migration, morphogenesis, and circuit assembly. Defects in EphR signalling have been associated with several pathologies including neurodevelopmental disorders (NDDs), intellectual disability (ID), and neurodegenerative diseases (NDs). Here, we review our current understanding of the complex and dynamic role of EphRs in the brain and discuss how deregulation of these receptors contributes to disease, highlighting their potential as valuable druggable targets.
Eph 受体（EphRs）是受体酪氨酸激酶（RTKs）中最大的家族，在发育中的大脑中大量表达，并在神经发生的不同阶段发挥重要作用，从神经干细胞（NSC）命运特化到神经迁移、形态发生和回路组装。EphR 信号的缺陷与几种病理学有关，包括神经发育障碍（NDDs）、智力障碍（ID）和神经退行性疾病（NDs）。在这里，我们回顾了我们目前对 EphRs 在大脑中复杂和动态作用的理解，并讨论了这些受体的失调如何导致疾病，强调了它们作为有价值的可用药靶点的潜力。
