Department of Systems Biology and Engineering, Silesian University of Technology, Akademicka 2A, Gliwice, 44-100, Poland.
A. Chełkowski Institute of Physics, University of Silesia in Katowice, 75 Pułku Piechoty 1a, Chorzów, 41- 500, Poland.
Sci Rep. 2024 Nov 6;14(1):26951. doi: 10.1038/s41598-024-77575-4.
Compounds that can induce oxidative stress in cancer cells while remaining nontoxic to healthy cells are extremely promising for potential anticancer drugs. 2,2':6',2''-terpyridine-metal complexes possess these properties. The high level of activity (IC = 0.605 µM) of 2,2':6',2''-terpyridine-metal complexes on lung, breast, pancreatic, and glioblastoma multiforme cancer lines and their selectivity (SI > 41.32) on human normal fibroblasts were confirmed and presented in this paper. The mechanism of action of these compounds is associated with the generation of reactive oxygen species, which affects several cellular pathways and signals. The results demonstrate that 2,2':6',2''-terpyridine-metal complexes affect cell cycle inhibition in the G0/G1 phase as well as the activation of apoptosis and autophagy cell death. These results were confirmed in several independent studies, including experiments measuring the fluorescence levels of reactive oxygen species, flow cytometry, and gene and protein analysis.
能够在不伤害健康细胞的情况下诱导癌细胞产生氧化应激的化合物，对于潜在的抗癌药物来说极具前景。2,2':6',2''-三联吡啶金属配合物具有这些特性。本文证实并介绍了 2,2':6',2''-三联吡啶金属配合物在肺癌、乳腺癌、胰腺癌和多形性胶质母细胞瘤癌细胞系上的高活性（IC=0.605 µM）和对人正常成纤维细胞的高选择性（SI>41.32）。这些化合物的作用机制与活性氧的产生有关，这会影响多个细胞通路和信号。研究结果表明，2,2':6',2''-三联吡啶金属配合物会抑制细胞周期进入 G0/G1 期，并激活细胞凋亡和自噬死亡。这些结果在包括测量活性氧荧光水平、流式细胞术以及基因和蛋白分析在内的几项独立研究中得到了证实。
