Department of Gynecology, Ningbo No.2 Hospital, Ningbo, 315010, Zhejiang, China.
Department of Endocrinology, Ningbo No.2 Hospital, Ningbo, 315010, Zhejiang, China.
Sci Rep. 2024 Nov 6;14(1):26987. doi: 10.1038/s41598-024-77886-6.
We estimated the association between combined exposure to air pollutants and the development of cardiometabolic multimorbidity (CM) and all-cause mortality. An air pollution score was calculated to determine the combined exposure to five air pollutants. CM was defined as the instance of at least two types of diseases. A genetic risk score (GRS) was calculated for each individual. A multistate regression model was used to investigate the effect of the combined associations of air pollutants on each stage of CM progression. After multivariable adjustment, the air pollution score was related with greater susceptibility of CM and all-cause mortality, and those with a high GRS for cardiovascular disease (CVD) or coronary heart disease (CHD) and a high air pollution score had a greater susceptibility of incident CM and all-cause mortality. The multistate model revealed that the greater air pollution score was connected with the susceptibility of progressing from disease-free baseline to having one cardiometabolic disease, and next to CM, and eventually to death. Combined exposure to five air pollutants were related with greater susceptibility of CM and all-cause mortality in a dose-dependent style and is related with the progression of CM and with all-cause mortality.
我们评估了空气污染物联合暴露与心血管代谢性多疾病（CM）和全因死亡率发展之间的关联。计算了空气污染评分以确定五种空气污染物的联合暴露情况。CM 定义为至少两种疾病的发生。为每个个体计算了遗传风险评分（GRS）。使用多状态回归模型来研究空气污染物联合关联对 CM 进展各个阶段的影响。在进行多变量调整后，空气污染评分与 CM 和全因死亡率的更高易感性相关，并且那些心血管疾病（CVD）或冠心病（CHD）的 GRS 较高且空气污染评分较高的人更易发生 CM 和全因死亡率。多状态模型表明，空气污染评分越高，从无疾病基线进展到患有一种心血管代谢疾病，再到 CM，最终到死亡的易感性就越大。五种空气污染物的联合暴露与 CM 和全因死亡率的更高易感性呈剂量依赖性相关，与 CM 的进展和全因死亡率相关。
