Goshtasbi Khodayar, Tawk Karen, Khosravi Pooya, Abouzari Mehdi, Djalilian Hamid R
Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, USA.
Department of Biomedical Engineering, University of California, Irvine, CA, USA.
Ann Otol Rhinol Laryngol. 2025 Feb;134(2):125-133. doi: 10.1177/00034894241297594. Epub 2024 Nov 6.
To evaluate the efficacy of a smartphone-based application providing tinnitus-specific cognitive behavioral therapy and customized sound therapy for tinnitus.
In a prospective randomized controlled trial, the treatment group participated in daily sound therapy and weekly interactive CBT modules, and the control group did not receive the program (waitlisted). Outcome measures after 8 weeks included the Tinnitus Functional Index (TFI), Generalized Anxiety Disorder (GAD-7), Patient Health Questionnaire (PHQ-9), Perceived Stress Scale (PSS), and Pittsburgh Sleep Quality Index (PSQI).
Ninety-two patients (mean age = 57.2 ± 11.9 years) were included. The treatment (n = 47) and control (n = 45) cohorts had similar TFI, PHQ-9, GAD-7, PSS, and PSQI scores at presentation (all > .05). Treatment-group patients had significantly higher improvements than controlled patients in their TFI (16.7 ± 14.9 vs 1.9 ± 10.8, < .001), PHQ-9 (1.9 ± 4.2 vs -0.7 ± 3.4, = .002), GAD-7 (1.1 ± 3.6 vs -0.9 ± 3.3, = .009), and PSQI scores (2.5 ± 3.2 vs -1.1 ± 2.1, < .001). Treatment-group subjects also significantly improved in 7 of the 8 TFI domains (all < .05). TFI improvements of ≥20 occurred in 18 (38.3%) treatment subjects. Of the 9 treatment-group patients presenting with moderate-severe depression, 4 (44.4%) improved to minimal depression. Of the 4 treatment-group patients with moderate-severe anxiety, 2 (50.0%) improved to minimal anxiety. Of the 17 treatment-group patients with moderate-severe sleep difficulties, 10 (55.6%) had considerable sleep improvement.
This novel smartphone application providing cognitive behavioral therapy and customized sound therapy was effective in reducing symptom severity and improving anxiety, sleep, and mood for tinnitus patients.
评估一款基于智能手机的应用程序对耳鸣患者提供耳鸣特异性认知行为疗法和定制化声音疗法的疗效。
在一项前瞻性随机对照试验中，治疗组参与每日声音疗法和每周的交互式认知行为疗法模块，对照组不接受该项目（列入候补名单）。8周后的结果测量包括耳鸣功能指数（TFI）、广泛性焦虑障碍（GAD-7）、患者健康问卷（PHQ-9）、感知压力量表（PSS）和匹兹堡睡眠质量指数（PSQI）。
纳入92例患者（平均年龄=57.2±11.9岁）。治疗组（n=47）和对照组（n=45）在就诊时的TFI、PHQ-9、GAD-7、PSS和PSQI评分相似（均>0.05）。治疗组患者在TFI（16.7±14.9 vs 1.9±10.8，<0.001）、PHQ-9（1.9±4.2 vs -0.7±3.4，=0.002）、GAD-7（1.1±3.6 vs -0.9±3.3，=0.009）和PSQI评分（2.5±3.2 vs -1.1±2.1，<0.001）方面的改善明显高于对照组患者。治疗组受试者在8个TFI领域中的7个领域也有显著改善（均<0.05）。18名（38.3%）治疗组受试者的TFI改善≥20。在9例表现为中度至重度抑郁的治疗组患者中，4例（44.4%）改善为轻度抑郁。在4例中度至重度焦虑的治疗组患者中，2例（50.0%）改善为轻度焦虑。在17例中度至重度睡眠困难的治疗组患者中，10例（55.6%）的睡眠有显著改善。
这款提供认知行为疗法和定制化声音疗法的新型智能手机应用程序在减轻耳鸣患者的症状严重程度、改善焦虑、睡眠和情绪方面是有效的。
