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SMG-1 serves as a prognostic indicator for the radiotherapy response in head and neck squamous cell carcinoma xenografts and patients.

作者信息

Wang Xiaofeng, Zou Yuxia, Ding Ren-Bo, Lyu Xueying, Fu Yuanfeng, Zhou Xuejun, Sun Zhihua, Bao Jiaolin

机构信息

Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Hainan Medical University, Haikou 571199, China.

Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China.

出版信息

Acta Biochim Biophys Sin (Shanghai). 2024 Nov 4;56(12):1891-1894. doi: 10.3724/abbs.2024180.

DOI:10.3724/abbs.2024180
PMID:39506517
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11693865/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39de/11693865/929985231f6b/t2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39de/11693865/03a743670d50/t1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39de/11693865/929985231f6b/t2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39de/11693865/03a743670d50/t1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39de/11693865/929985231f6b/t2.jpg

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THO complex deficiency impairs DNA double-strand break repair via the RNA surveillance kinase SMG-1.THO 复合物缺陷通过 RNA 监测激酶 SMG-1 损害 DNA 双链断裂修复。
Nucleic Acids Res. 2022 Jun 24;50(11):6235-6250. doi: 10.1093/nar/gkac472.
2
MicroRNA-32 promotes ovarian cancer cell proliferation and motility by targeting SMG1.微小RNA-32通过靶向SMG1促进卵巢癌细胞增殖和运动。
Oncol Lett. 2020 Jul;20(1):733-741. doi: 10.3892/ol.2020.11624. Epub 2020 May 14.
3
DNMT1 Enhances the Radiosensitivity of HPV-Positive Head and Neck Squamous Cell Carcinomas via Downregulating SMG1.
DNA甲基转移酶1通过下调SMG1增强人乳头瘤病毒阳性头颈部鳞状细胞癌的放射敏感性。
Onco Targets Ther. 2020 May 15;13:4201-4211. doi: 10.2147/OTT.S227395. eCollection 2020.
4
LncRNA MAGI2-AS3 inhibits hepatocellular carcinoma cell proliferation and migration by targeting the miR-374b-5p/SMG1 signaling pathway.长链非编码 RNA MAGI2-AS3 通过靶向 miR-374b-5p/SMG1 信号通路抑制肝癌细胞增殖和迁移。
J Cell Physiol. 2019 Aug;234(10):18825-18836. doi: 10.1002/jcp.28521. Epub 2019 Mar 28.
5
SMG-1 inhibition by miR-192/-215 causes epithelial-mesenchymal transition in gastric carcinogenesis via activation of Wnt signaling.miR-192/-215 通过抑制 SMG-1 激活 Wnt 信号通路诱导胃癌发生上皮间质转化。
Cancer Med. 2018 Jan;7(1):146-156. doi: 10.1002/cam4.1237. Epub 2017 Dec 13.
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Overexpression of serine/threonine-protein kinase-1 in pancreatic cancer tissue: Serine/threonine-protein kinase-1 knockdown increases the chemosensitivity of pancreatic cancer cells.
Mol Med Rep. 2015 Jul;12(1):475-81. doi: 10.3892/mmr.2015.3434. Epub 2015 Mar 5.
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Expression and significance of the novel tumor-suppressor gene SMG-1 in hepatocellular carcinoma.新型抑癌基因 SMG-1 在肝细胞癌中的表达及意义。
Oncol Rep. 2014 Jun;31(6):2569-78. doi: 10.3892/or.2014.3125. Epub 2014 Apr 2.
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SMG-1 suppresses CDK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways.SMG-1 通过调控 p53 和 Cdc25A 信号通路抑制 CDK2 表达和肿瘤生长。
Cell Cycle. 2013 Dec 15;12(24):3770-80. doi: 10.4161/cc.26660. Epub 2013 Oct 4.
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