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独立于肺毛细血管楔压的血流动力学标志物能够区分毛细血管前和毛细血管后运动诱发的肺动脉高压。

Hemodynamic markers independent of pulmonary capillary wedge pressure can discriminate between pre and postcapillary exercise-induced pulmonary hypertension.

作者信息

Montovano Margaret, Scheel Paul J, Cubero Salazar Ilton M, Hassoun Paul M, Tedford Ryan J, Hsu Steven

机构信息

Division of Cardiology, Department of Medicine The Johns Hopkins University School of Medicine Baltimore Maryland USA.

Division of Pulmonary and Critical Care Medicine, Department of Medicine The Johns Hopkins University School of Medicine Baltimore Maryland USA.

出版信息

Pulm Circ. 2024 Nov 6;14(4):e70002. doi: 10.1002/pul2.70002. eCollection 2024 Oct.

DOI:10.1002/pul2.70002
PMID:39507237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11538611/
Abstract

The discrimination between pre and postcapillary exercise-induced pulmonary hypertension relies on accurate measurement of pulmonary capillary wedge pressure, which can be unreliable. We found that exercise pulmonary artery compliance and right atrial pressure (AUC 0.88, 0.89, respectively) can differentiate subtypes of exercise-induced pulmonary hypertension in the absence of wedge pressure.

摘要

毛细血管前和毛细血管后运动诱发的肺动脉高压之间的鉴别依赖于肺毛细血管楔压的准确测量，而这可能并不可靠。我们发现，在没有楔压的情况下，运动肺动脉顺应性和右心房压力（曲线下面积分别为0.88、0.89）可以区分运动诱发的肺动脉高压的亚型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da06/11538611/440c5127e657/PUL2-14-e70002-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da06/11538611/440c5127e657/PUL2-14-e70002-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da06/11538611/440c5127e657/PUL2-14-e70002-g001.jpg

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本文引用的文献

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J Card Fail. 2023 Sep;29(9):1261-1272. doi: 10.1016/j.cardfail.2023.04.009. Epub 2023 May 5.
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Heart Failure With Preserved Ejection Fraction: JACC Scientific Statement.射血分数保留的心力衰竭：美国心脏病学会杂志科学声明。
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Prognostic Value of Exercise as Compared to Resting Pulmonary Hypertension in Patients with Normal or Mildly Elevated Pulmonary Arterial Pressure.
与静息肺动脉高压相比，运动对肺动脉压力正常或轻度升高患者的预后价值。
Am J Respir Crit Care Med. 2022 Dec 1;206(11):1418-1423. doi: 10.1164/rccm.202112-2856LE.
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Right Ventricular and Right Atrial Function Are Less Compromised in Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction: A Comparison With Pulmonary Arterial Hypertension With Similar Pressure Overload.右心室和右心房功能在射血分数保留的心力衰竭继发肺动脉高压中受损较小：与相似压力超负荷的肺动脉高压的比较。
Circ Heart Fail. 2022 Feb;15(2):e008726. doi: 10.1161/CIRCHEARTFAILURE.121.008726. Epub 2021 Dec 23.
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Right Atrial Pressure During Exercise Predicts Survival in Patients With Pulmonary Hypertension.运动时右心房压力可预测肺动脉高压患者的生存情况。
J Am Heart Assoc. 2020 Nov 17;9(22):e018123. doi: 10.1161/JAHA.120.018123. Epub 2020 Nov 4.
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