Ngowi Elisamia, Juneja Zeenat, Gabone Jacqueline, Bulimba Maria, Ebrahim Mohamedraza, Abdallah Yaser
Department of Paediatrics and Child Health, Aga Khan Hospital Tanzania, Dar Es Salaam 2289, Tanzania.
Department of Paediatrics and Child Health, Aga Khan University, Dar Es Salaam 38129, Tanzania.
Radiol Case Rep. 2024 Oct 23;20(1):210-214. doi: 10.1016/j.radcr.2024.09.149. eCollection 2025 Jan.
Acute necrotizing encephalopathy is a rare, severe neurological condition, characterized by symmetrical necrotic brain lesions affecting the thalamus, cerebral white matter, brain stem, and cerebellum. Diagnosis relies on characteristic clinical and radiological features. We describe a 10-month-old female infant presenting with multiple seizures following a brief febrile upper respiratory illness. MRI of the brain showed bilateral symmetrical abnormal signal intensities involving both thalami and caudate nucleus, consistent with ANE. Management of ANE is symptom-related but high-dose steroids and IVIG have been used. This case highlights the importance of recognizing ANE beyond its usual geographic distribution. Early recognition and prompt management help improve outcomes.
急性坏死性脑病是一种罕见的严重神经系统疾病，其特征是影响丘脑、脑白质、脑干和小脑的对称性坏死性脑病变。诊断依赖于特征性的临床和影像学表现。我们描述了一名10个月大的女婴，在短暂的发热性上呼吸道疾病后出现多次癫痫发作。脑部MRI显示双侧丘脑和尾状核有对称的异常信号强度，符合急性坏死性脑病的表现。急性坏死性脑病的治疗以对症治疗为主，但也使用了大剂量类固醇和静脉注射免疫球蛋白。该病例强调了在其常见地理分布范围之外认识急性坏死性脑病的重要性。早期识别和及时治疗有助于改善预后。
