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达拉斯循环性死亡后器官捐献移植峰会:通过流程改进、更广泛利用和创新来扩大循环性死亡后器官捐献程序。

The Dallas Donation after Circulatory Death Transplantation Summit: expanding donation after circulatory death procedures through process improvement, broader utilization, and innovation.

作者信息

Finotti Michele, Wall Anji, D'Alessandro Anthony, Schwartz Gary, Sonnenday Chris, Goldberg David, Shah Ashish, Friend Peter, Orlowski Jeff P, McKenna Greg, Newton Steve, Adams Brad, Chapman William C, Mathur Amit, Abouljoud Marwan, Pruett Tim, Hessheimer Amelia, Trotter James F, Asrani Sumeet K, Testa Giuliano

机构信息

Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX, USA.

Hepatobiliary and General Surgery Unit, Regional Hospital Treviso, DISCOG, University of Padua, Padua, Italy.

出版信息

Hepatobiliary Surg Nutr. 2024 Oct 1;13(5):824-836. doi: 10.21037/hbsn-23-503. Epub 2024 Apr 25.

DOI:10.21037/hbsn-23-503
PMID:39507724
原文链接:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11534777/
Abstract

Despite a significant increase in utilization over the past decade, the number of donation after circulatory death (DCD) organs that are procured and transplanted in the United States (US) remains well below its potential. There is still room for expansion, as utilizing DCD organs to the fullest extent is currently the most viable solution to the persistent mismatch between supply and demand in transplantation. We convened a multidisciplinary transplantation summit to examine various aspects of DCD, with faculty members from around the world with clinical and academic interest in DCD donation and transplantation, including abdominal and cardiothoracic surgeons, organ procurement organization directors, hepatologists, and gastroenterologists. The conference focused on identifying barriers to DCD organ utilization and strategies to overcome these barriers. We divide the barriers to DCD utilization into three mains categories: (I) policy and process variation; (II) logistical and transportation challenges; and (III) higher risk perceptions related to DCD outcomes. For each barrier, we proposed a variety of solutions, providing an overview of the status of DCD donation in the US and suggestions on how to increase the use of DCD. There is a specific focus on ex situ machine perfusion, normothermic regional perfusion, and other opportunities to expand DCD utilization without negatively impacting recipient outcomes.

摘要

尽管在过去十年中利用率显著提高,但在美国获取并移植的循环性死亡后器官捐赠(DCD)的数量仍远低于其潜力。仍有扩展空间,因为充分利用DCD器官目前是解决移植中持续存在的供需不匹配问题的最可行解决方案。我们召集了一次多学科移植峰会,以审视DCD的各个方面,参会教员来自世界各地,对DCD捐赠和移植有着临床和学术兴趣,包括腹部和心胸外科医生、器官获取组织主任、肝病学家和胃肠病学家。会议重点在于确定DCD器官利用的障碍以及克服这些障碍的策略。我们将DCD利用的障碍分为三大类:(I)政策和流程差异;(II)后勤和运输挑战;以及(III)与DCD结果相关的更高风险认知。针对每个障碍,我们提出了多种解决方案,概述了美国DCD捐赠的现状以及关于如何增加DCD使用的建议。特别关注了体外机器灌注、常温区域灌注以及其他在不负面影响受者结果的情况下扩大DCD利用的机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a11/11534777/3918475bf8dc/hbsn-13-05-824-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a11/11534777/5ad413d62fb8/hbsn-13-05-824-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a11/11534777/144b1606c437/hbsn-13-05-824-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a11/11534777/3918475bf8dc/hbsn-13-05-824-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a11/11534777/5ad413d62fb8/hbsn-13-05-824-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a11/11534777/144b1606c437/hbsn-13-05-824-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a11/11534777/3918475bf8dc/hbsn-13-05-824-f3.jpg

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本文引用的文献

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2
Six-month abdominal transplant recipient outcomes from donation after circulatory death heart donors: A retrospective analysis by procurement technique.移植后 6 个月腹部器官受者结局:供体心死亡后循环标准下的回顾性分析:按获取技术的分类
Am J Transplant. 2023 Jul;23(7):987-995. doi: 10.1016/j.ajt.2023.04.021. Epub 2023 Apr 21.
3
American Society of Transplant Surgeons recommendations on best practices in donation after circulatory death organ procurement.
美国移植外科学会关于循环死亡器官捐献获取的最佳实践建议。
Am J Transplant. 2023 Feb;23(2):171-179. doi: 10.1016/j.ajt.2022.10.009. Epub 2023 Jan 12.
4
Despite Increasing Costs, Perfusion Machines Expand the Donor Pool of Livers and Could Save Lives.尽管成本不断增加,但灌注机扩大了肝脏供体的来源,有可能拯救生命。
J Surg Res. 2023 Mar;283:42-51. doi: 10.1016/j.jss.2022.10.002. Epub 2022 Nov 8.
5
Assessment of donor quality and risk of graft failure after liver transplantation: The ID EAL score.肝移植后供体质量评估和移植物失败风险:ID EAL 评分。
Am J Transplant. 2022 Dec;22(12):2921-2930. doi: 10.1111/ajt.17191. Epub 2022 Sep 22.
6
Nonutilization of Kidneys From Donors After Circulatory Determinant of Death.循环判定死亡后供体肾脏的未利用情况
Transplant Direct. 2022 May 13;8(6):e1331. doi: 10.1097/TXD.0000000000001331. eCollection 2022 Jun.
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Good post-transplant outcomes using liver donors after circulatory death when applying strict selection criteria: A propensity-score matched-cohort study.应用严格选择标准时,使用循环死亡后肝脏供体可获得良好的移植后结果:倾向评分匹配队列研究。
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Variation in donation after circulatory death hospital policies in a single donor service area.在一个供体服务区内,关于循环死亡后捐献的医院政策存在差异。
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