Finotti Michele, Wall Anji, D'Alessandro Anthony, Schwartz Gary, Sonnenday Chris, Goldberg David, Shah Ashish, Friend Peter, Orlowski Jeff P, McKenna Greg, Newton Steve, Adams Brad, Chapman William C, Mathur Amit, Abouljoud Marwan, Pruett Tim, Hessheimer Amelia, Trotter James F, Asrani Sumeet K, Testa Giuliano
Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX, USA.
Hepatobiliary and General Surgery Unit, Regional Hospital Treviso, DISCOG, University of Padua, Padua, Italy.
Hepatobiliary Surg Nutr. 2024 Oct 1;13(5):824-836. doi: 10.21037/hbsn-23-503. Epub 2024 Apr 25.
Despite a significant increase in utilization over the past decade, the number of donation after circulatory death (DCD) organs that are procured and transplanted in the United States (US) remains well below its potential. There is still room for expansion, as utilizing DCD organs to the fullest extent is currently the most viable solution to the persistent mismatch between supply and demand in transplantation. We convened a multidisciplinary transplantation summit to examine various aspects of DCD, with faculty members from around the world with clinical and academic interest in DCD donation and transplantation, including abdominal and cardiothoracic surgeons, organ procurement organization directors, hepatologists, and gastroenterologists. The conference focused on identifying barriers to DCD organ utilization and strategies to overcome these barriers. We divide the barriers to DCD utilization into three mains categories: (I) policy and process variation; (II) logistical and transportation challenges; and (III) higher risk perceptions related to DCD outcomes. For each barrier, we proposed a variety of solutions, providing an overview of the status of DCD donation in the US and suggestions on how to increase the use of DCD. There is a specific focus on ex situ machine perfusion, normothermic regional perfusion, and other opportunities to expand DCD utilization without negatively impacting recipient outcomes.
尽管在过去十年中利用率显著提高,但在美国获取并移植的循环性死亡后器官捐赠(DCD)的数量仍远低于其潜力。仍有扩展空间,因为充分利用DCD器官目前是解决移植中持续存在的供需不匹配问题的最可行解决方案。我们召集了一次多学科移植峰会,以审视DCD的各个方面,参会教员来自世界各地,对DCD捐赠和移植有着临床和学术兴趣,包括腹部和心胸外科医生、器官获取组织主任、肝病学家和胃肠病学家。会议重点在于确定DCD器官利用的障碍以及克服这些障碍的策略。我们将DCD利用的障碍分为三大类:(I)政策和流程差异;(II)后勤和运输挑战;以及(III)与DCD结果相关的更高风险认知。针对每个障碍,我们提出了多种解决方案,概述了美国DCD捐赠的现状以及关于如何增加DCD使用的建议。特别关注了体外机器灌注、常温区域灌注以及其他在不负面影响受者结果的情况下扩大DCD利用的机会。