大鼠进食后肝脏核糖体聚集的时间依赖性变化。

Time-dependent changes in aggregation of hepatic ribosomes after meal feeding of rats.

作者信息

Yokogoshi H, Yoshida A

出版信息

J Nutr. 1986 Mar;116(3):472-4. doi: 10.1093/jn/116.3.472.

DOI:10.1093/jn/116.3.472

Abstract

The effects of consumption of a meal on changes in aggregation of hepatic ribosomes were studied. Hepatic ribosomes were aggregated very rapidly, within 10-20 min, after meal feeding a 25% casein diet. This response of hepatic ribosomes is faster than the half-life of mRNAs of some liver proteins. Therefore, when rats are fed, the translational changes in protein synthesis (polysome pattern) might be quickly affected by the dietary protein, and the observed aggregation of ribosomes could indicate the state of protein synthesis in liver in vivo.

摘要

研究了进食一顿饭对肝核糖体聚集变化的影响。在给大鼠喂食25%酪蛋白饮食后，肝核糖体在10 - 20分钟内迅速聚集。肝核糖体的这种反应比某些肝脏蛋白质mRNA的半衰期还要快。因此，当给大鼠喂食时，蛋白质合成中的翻译变化（多核糖体模式）可能会迅速受到膳食蛋白质的影响，观察到的核糖体聚集可能表明体内肝脏中蛋白质合成的状态。