嵌合抗原受体T细胞治疗后发生噬血细胞性淋巴组织细胞增生症并伴有暴发性紫癜、血培养阳性的致死性播散性毛霉目感染
Lethal Disseminated Mucorales Infection With Positive Blood Cultures With Purpura Fulminans Complicating Hemophagocytic Lymphohistiocytosis After Chimeric Antigen Receptor T-Cell Therapy.
作者信息
Matsuo Takahiro, Wurster Sebastian, Ivan Doina, Hicklen Rachel, McConn Kelly, Bagwell Kelli A, Khawaja Fareed, Chemaly Roy F, Kontoyiannis Dimitrios P
机构信息
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
出版信息
Open Forum Infect Dis. 2024 Oct 29;11(11):ofae647. doi: 10.1093/ofid/ofae647. eCollection 2024 Nov.
We report a case of fulminant Mucorales fungemia in a heavily immunosuppressed cancer patient with hemophagocytic lymphohistiocytosis following CD70-targeted chimeric antigen receptor T-cell therapy. Although rare, Mucorales can cause true fungemia in a broad spectrum of hosts, with a range of manifestations from isolated fungemia to fungemia being part of widely disseminated, high-burden infection.
我们报告了一例在接受CD70靶向嵌合抗原受体T细胞治疗后发生噬血细胞性淋巴组织细胞增生症的重度免疫抑制癌症患者中出现的暴发性毛霉目真菌血症病例。尽管罕见，但毛霉目可在广泛的宿主中引起真正的真菌血症，其表现范围从孤立的真菌血症到作为广泛播散、高负荷感染一部分的真菌血症。
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