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嵌合抗原受体T细胞治疗后发生噬血细胞性淋巴组织细胞增生症并伴有暴发性紫癜、血培养阳性的致死性播散性毛霉目感染

Lethal Disseminated Mucorales Infection With Positive Blood Cultures With Purpura Fulminans Complicating Hemophagocytic Lymphohistiocytosis After Chimeric Antigen Receptor T-Cell Therapy.

作者信息

Matsuo Takahiro, Wurster Sebastian, Ivan Doina, Hicklen Rachel, McConn Kelly, Bagwell Kelli A, Khawaja Fareed, Chemaly Roy F, Kontoyiannis Dimitrios P

机构信息

Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

出版信息

Open Forum Infect Dis. 2024 Oct 29;11(11):ofae647. doi: 10.1093/ofid/ofae647. eCollection 2024 Nov.

DOI:10.1093/ofid/ofae647
PMID:39507882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11540139/
Abstract

We report a case of fulminant Mucorales fungemia in a heavily immunosuppressed cancer patient with hemophagocytic lymphohistiocytosis following CD70-targeted chimeric antigen receptor T-cell therapy. Although rare, Mucorales can cause true fungemia in a broad spectrum of hosts, with a range of manifestations from isolated fungemia to fungemia being part of widely disseminated, high-burden infection.

摘要

我们报告了一例在接受CD70靶向嵌合抗原受体T细胞治疗后发生噬血细胞性淋巴组织细胞增生症的重度免疫抑制癌症患者中出现的暴发性毛霉目真菌血症病例。尽管罕见，但毛霉目可在广泛的宿主中引起真正的真菌血症，其表现范围从孤立的真菌血症到作为广泛播散、高负荷感染一部分的真菌血症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0c/11540139/4c3bbca736d8/ofae647f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0c/11540139/22c8a7270f03/ofae647f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0c/11540139/4c3bbca736d8/ofae647f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0c/11540139/22c8a7270f03/ofae647f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0c/11540139/4c3bbca736d8/ofae647f2.jpg

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Lethal Disseminated Mucorales Infection With Positive Blood Cultures With Purpura Fulminans Complicating Hemophagocytic Lymphohistiocytosis After Chimeric Antigen Receptor T-Cell Therapy.嵌合抗原受体T细胞治疗后发生噬血细胞性淋巴组织细胞增生症并伴有暴发性紫癜、血培养阳性的致死性播散性毛霉目感染
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本文引用的文献

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Recurrent  central venous catheter infection in a five year old child on long term parenteral nutrition for short gut syndrome: could gut translocation be responsible?一名因短肠综合征接受长期肠外营养的5岁儿童反复发生中心静脉导管感染：肠道细菌易位是病因吗？
Med Mycol Case Rep. 2024 Jul 14;45:100661. doi: 10.1016/j.mmcr.2024.100661. eCollection 2024 Sep.
2
The Burden of Invasive Fungal Disease Following Chimeric Antigen Receptor T-Cell Therapy and Strategies for Prevention.嵌合抗原受体T细胞疗法后侵袭性真菌病的负担及预防策略
Open Forum Infect Dis. 2024 Mar 13;11(6):ofae133. doi: 10.1093/ofid/ofae133. eCollection 2024 Jun.
3
The Brief Case: Yeast, chlamydospores, and hyphae-a case of disseminated mucormycosis.
简要病例：酵母、厚垣孢子和菌丝——一例播散性毛霉病病例
J Clin Microbiol. 2024 Jun 12;62(6):e0163823. doi: 10.1128/jcm.01638-23.
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Disseminated Histoplasmosis in a Patient with Myelofibrosis on Ruxolitinib: A Case Report and Review of the Literature on Ruxolitinib-Associated Invasive Fungal Infections.鲁索替尼治疗的骨髓纤维化患者发生播散性组织胞浆菌病：一例报告及鲁索替尼相关侵袭性真菌感染的文献综述
J Fungi (Basel). 2024 Mar 31;10(4):264. doi: 10.3390/jof10040264.
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Mucormycosis after CD19 chimeric antigen receptor T-cell therapy: results of a US Food and Drug Administration adverse events reporting system analysis and a review of the literature.嵌合抗原受体 T 细胞治疗后毛霉菌病：美国食品和药物管理局不良事件报告系统分析结果及文献复习。
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Transpl Infect Dis. 2023 Nov;25 Suppl 1:e14157. doi: 10.1111/tid.14157. Epub 2023 Oct 3.
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