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新型三唑衍生物的合成及其从水溶液中去除重金属的潜在应用和抗菌活性。

Synthesis of new triazole derivatives and their potential applications for removal of heavy metals from aqueous solution and antibacterial activities.

作者信息

Xu Chunyun, Yang Na, Yu Haichun, Wang Xiaojing

机构信息

Department of Dermatology, Maternity and Child Health Hospital of Qinhuangdao, Qinhuangdao, China.

出版信息

Front Chem. 2024 Oct 23;12:1473097. doi: 10.3389/fchem.2024.1473097. eCollection 2024.

DOI:10.3389/fchem.2024.1473097
PMID:39508035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11537928/
Abstract

In this paper, triazole derivatives were prepared by a three-step mild reaction using carbon disulfide as starting material. In face of microbial threats, we found that compound 3-cyclopropyl-[1,2,4]triazolo [3,4-b][1,3,4]thiadiazole-6-thiol () has good antibacterial activity, inhibition and clearance ability against biofilms, low hemolytic activity and toxicity, good anti-inflammatory activity. At the same time, we found that and series compounds have good metal ion scavenging ability, with removal rates of series ranging from 47% to 67% and series ranging from 67% to 87%.

摘要

在本文中，以二硫化碳为起始原料，通过三步温和反应制备了三唑衍生物。面对微生物威胁，我们发现化合物3-环丙基-[1,2,4]三唑并[3,4-b][1,3,4]噻二唑-6-硫醇（）具有良好的抗菌活性、对生物膜的抑制和清除能力、低溶血活性和毒性、良好的抗炎活性。同时，我们发现和系列化合物具有良好的金属离子清除能力，系列的去除率在47%至67%之间，系列的去除率在67%至87%之间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/34b3631c1b60/fchem-12-1473097-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/62e6894380f3/fchem-12-1473097-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/12bd1e100a91/FCHEM_fchem-2024-1473097_wc_sch1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/02299e878c64/fchem-12-1473097-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/daf72b9352ce/fchem-12-1473097-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/051612581a26/fchem-12-1473097-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/61df4e430121/fchem-12-1473097-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/529c54f5fda0/fchem-12-1473097-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/1728f82781c7/fchem-12-1473097-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/aa122597befd/fchem-12-1473097-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/34b3631c1b60/fchem-12-1473097-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/62e6894380f3/fchem-12-1473097-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/12bd1e100a91/FCHEM_fchem-2024-1473097_wc_sch1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/02299e878c64/fchem-12-1473097-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/daf72b9352ce/fchem-12-1473097-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/051612581a26/fchem-12-1473097-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/61df4e430121/fchem-12-1473097-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/529c54f5fda0/fchem-12-1473097-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/1728f82781c7/fchem-12-1473097-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/aa122597befd/fchem-12-1473097-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca6/11537928/34b3631c1b60/fchem-12-1473097-g009.jpg

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