Spontaneous corneal perforation and extrusion of intraocular contents in premature infants.

Unilateral spontaneous corneal perforation with expulsion of intraocular contents is reported in two very small, high risk premature neonates. The one surviving infant demonstrated unilateral microphthalmos with aphakia and a small leukoma. The cause of this phenomenon is not clear, and measures which might be taken to prevent its occurrence are not obvious.