Novel indole based fused triazole-thiadiazole derivatives as anti-diabetic agents: and approaches.

The current research presents novel library of indole derived fused triazole-thiadiazole derivatives (1-17) for treatment of diabetes mellitus. These compounds were synthesized by treating 2-(1H-indol-3-yl)acetic acid with hydrazinecarbothiohydrazide followed by treating the resultant compound with substituted benzoic acid. Structural validation was achieved spectroscopically (HNMR, CNMR and HREI-MS). The synthesized compounds were subjected to biological evaluation to assess their potential as anti-diabetic. Molecular docking study was employed to investigate the binding interactions of these analogs with relevant proteins. ADMET analysis was used to predict their drug-like properties. Notably, compound- (IC = and μM) bearing -substituted F atom exhibited the highest potency due to strong inhibitory interactions through hydrogen bonding. This study identifies promising compounds with anti-diabetic activity, paving the way for the treatment of diabetes mellitus.