Centre for Medical Education, School of Medicine, Cardiff University, Cardiff, UK.
Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
Acta Derm Venereol. 2024 Nov 7;104:adv41120. doi: 10.2340/actadv.v104.41120.
This study systematically analysed peer-reviewed publications describing validation aspects of the Dermatology Life Quality Index (DLQI) and used Naicker's Critically Appraising for Antiracism Tool to assess risk of racial bias. Seven online databases were searched from 1994 until 2022 for articles containing DLQI validation data. Methodology followed PRISMA guidelines, the protocol was registered in PROSPERO, and articles reviewed independently by two assessors. Of 1,717 screened publications, 207 articles including 58,828 patients from > 49 different countries and 41 diseases met the inclusion criteria. The DLQI demonstrated strong test-retest reliability; 43 studies confirmed good internal consistency. Twelve studies were performed using anchors to assess change responsiveness with effect sizes from small to large, giving confidence that the DLQI responds appropriately to change. Forty-two studies tested known-groups validity, providing confidence in construct and use of the DLQI over many parameters, including disease severity, anxiety, depression, stigma, scarring, well-being, sexual function, disease location and duration. DLQI correlation was demonstrated with 119 Patient Reported Outcomes/Quality of Life measures in 207 studies. Only 15% of studies explicitly recruited minority ethnic participants; 3.9% stratified results by race/ethnicity. This review summarizes knowledge concerning DLQI validation, confirms many strengths of the DLQI and identifies areas for further validation.
本研究系统分析了描述皮肤病生活质量指数（DLQI）验证方面的同行评审出版物，并使用 Naicker 的反种族主义批判性评估工具来评估种族偏见的风险。从 1994 年到 2022 年，在七个在线数据库中搜索了包含 DLQI 验证数据的文章。方法遵循 PRISMA 指南，该方案已在 PROSPERO 中注册，由两名评估员独立审查文章。在筛选出的 1717 篇出版物中，有 207 篇文章包括来自 49 个以上不同国家和 41 种疾病的 58828 名患者，符合纳入标准。DLQI 显示出较强的重测信度；43 项研究证实了良好的内部一致性。有 12 项研究使用锚定物来评估反应变化的响应性，其效果大小从小到大，这使人们有信心认为 DLQI 能够对变化做出适当反应。42 项研究检验了已知组有效性，在包括疾病严重程度、焦虑、抑郁、耻辱感、疤痕、幸福感、性功能、疾病位置和持续时间在内的许多参数方面，对 DLQI 的结构和使用提供了信心。在 207 项研究中，DLQI 与 119 项患者报告的结果/生活质量测量结果相关。只有 15%的研究明确招募少数民族参与者；3.9%的研究按种族/民族进行分层。本综述总结了关于 DLQI 验证的知识，确认了 DLQI 的许多优势，并确定了进一步验证的领域。
