• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Drug-induced liver injury during valproic acid and cenobamate coadministration: a direct consequence or an unforeseen event?

作者信息

Giannelli Thomas, Falcicchio Giovanni

机构信息

Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari "Aldo Moro", Piazza G. Cesare, 11, Bari, 70124, Italy.

出版信息

Neurol Sci. 2025 Mar;46(3):1419-1420. doi: 10.1007/s10072-024-07864-3. Epub 2024 Nov 7.

DOI:10.1007/s10072-024-07864-3
PMID:39508936
Abstract
摘要

相似文献

1
Drug-induced liver injury during valproic acid and cenobamate coadministration: a direct consequence or an unforeseen event?丙戊酸与司替戊醇联合使用期间的药物性肝损伤：是直接后果还是意外事件？
Neurol Sci. 2025 Mar;46(3):1419-1420. doi: 10.1007/s10072-024-07864-3. Epub 2024 Nov 7.
2
The potential protective effect of liraglutide on valproic acid induced liver injury in rats: Targeting HMGB1/RAGE axis and RIPK3/MLKL mediated necroptosis.利拉鲁肽对丙戊酸诱导的大鼠肝损伤的潜在保护作用：靶向高迁移率族蛋白B1/晚期糖基化终末产物受体轴及受体相互作用蛋白激酶3/混合谱系激酶结构域样蛋白介导的坏死性凋亡
Cell Biochem Funct. 2023 Dec;41(8):1209-1219. doi: 10.1002/cbf.3855. Epub 2023 Sep 28.
3
Safety assessment of cenobamate: real-world adverse event analysis from the FAERS database.司替戊醇的安全性评估：来自FAERS数据库的真实世界不良事件分析。
Front Pharmacol. 2024 Mar 15;15:1369384. doi: 10.3389/fphar.2024.1369384. eCollection 2024.
4
Cenobamate: Neuroprotective Potential of a New Antiepileptic Drug.丙戊酸钠：一种新型抗癫痫药物的神经保护潜力。
Neurochem Res. 2021 Mar;46(3):439-446. doi: 10.1007/s11064-020-03188-8. Epub 2020 Nov 30.
5
Effects of minocycline and valproic acid coadministration on atazanavir plasma concentrations in human immunodeficiency virus-infected adults receiving atazanavir-ritonavir.米诺环素与丙戊酸联合给药对接受阿扎那韦-利托那韦治疗的人类免疫缺陷病毒感染成人阿扎那韦血药浓度的影响。
Antimicrob Agents Chemother. 2008 Sep;52(9):3035-9. doi: 10.1128/AAC.00194-08. Epub 2008 Jun 23.
6
Cost-effectiveness of cenobamate for focal seizures in people with drug-resistant epilepsy.司替戊醇治疗耐药性癫痫患者局灶性癫痫发作的成本效益
Epilepsia. 2023 Apr;64(4):843-856. doi: 10.1111/epi.17506. Epub 2023 Feb 14.
7
Cenobamate (YKP3089) as adjunctive treatment for uncontrolled focal seizures in a large, phase 3, multicenter, open-label safety study.cenobamate（YKp3089）作为一种附加治疗，用于治疗大型、3 期、多中心、开放性标签安全性研究中的未控制局灶性发作。
Epilepsia. 2020 Jun;61(6):1099-1108. doi: 10.1111/epi.16525. Epub 2020 May 12.
8
Dose reduction and discontinuation of concomitant antiseizure medications after initiating cenobamate: A retrospective review.在起始使用苯巴比妥后减少和停用伴随抗癫痫药物：回顾性研究。
Epilepsy Res. 2023 Nov;197:107242. doi: 10.1016/j.eplepsyres.2023.107242. Epub 2023 Oct 10.
9
Long-term safety of adjunctive cenobamate in patients with uncontrolled focal seizures: Open-label extension of a randomized clinical study.辅助用考尼伐坦长期治疗未得到控制的局灶性癫痫发作患者的安全性：一项随机临床试验的开放性扩展研究。
Epilepsia. 2021 Sep;62(9):2142-2150. doi: 10.1111/epi.17007. Epub 2021 Jul 13.
10
Cenobamate add-on therapy for drug-resistant focal epilepsy.添加用盐酸依考尼萨林治疗耐药性局灶性癫痫
Cochrane Database Syst Rev. 2024 Aug 1;8(8):CD014941. doi: 10.1002/14651858.CD014941.pub2.

本文引用的文献

1
Cenobamate as add-on therapy for drug resistant epilepsies: effectiveness, drug to drug interactions and neuropsychological impact. What have we learned from real word evidence?西诺巴胺作为耐药性癫痫的附加治疗：有效性、药物相互作用及神经心理学影响。我们从真实世界证据中学到了什么？
Front Pharmacol. 2023 Dec 21;14:1239152. doi: 10.3389/fphar.2023.1239152. eCollection 2023.
2
Valproic acid induced liver injury: An insight into molecular toxicological mechanism.丙戊酸诱导的肝损伤：分子毒理学机制的深入探讨。
Environ Toxicol Pharmacol. 2022 Oct;95:103967. doi: 10.1016/j.etap.2022.103967. Epub 2022 Sep 1.
3
Drug-induced liver injury: Pathogenesis, epidemiology, clinical features, and practical management.
药物性肝损伤：发病机制、流行病学、临床特征及实用管理。
Eur J Intern Med. 2022 Mar;97:26-31. doi: 10.1016/j.ejim.2021.10.035. Epub 2021 Nov 9.
4
Pharmacology of Cenobamate: Mechanism of Action, Pharmacokinetics, Drug-Drug Interactions and Tolerability.司替戊醇的药理学：作用机制、药代动力学、药物相互作用及耐受性
CNS Drugs. 2021 Jun;35(6):609-618. doi: 10.1007/s40263-021-00819-8. Epub 2021 May 16.
5
Valproic acid induced acute liver injury resulting in hepatic encephalopathy- a case report and literature review.丙戊酸致急性肝损伤并发肝性脑病——病例报告及文献复习
J Community Hosp Intern Med Perspect. 2018 Oct 15;8(5):311-314. doi: 10.1080/20009666.2018.1514933. eCollection 2018.