University School of Basic & Applied Sciences, Guru Gobind Singh Indraprastha University, Dwarka, New Delhi, 110078, India.
University School of Basic & Applied Sciences, Guru Gobind Singh Indraprastha University, Dwarka, New Delhi, 110078, India; Synthesis & In-Silico Drug Design Laboratory, Department of Chemistry, Acharya Narendra Dev College, University of Delhi, Kalkaji, New Delhi, 110 019, India.
Eur J Med Chem. 2025 Jan 5;281:117017. doi: 10.1016/j.ejmech.2024.117017. Epub 2024 Nov 1.
In recent years, viral infections such as COVID-19, Zika virus, Nipah virus, Ebola, Influenza, Monkeypox, and Dengue have substantially impacted global health. These outbreaks have led to heightened global health initiatives and collaborative efforts to address and mitigate these significant threats effectively. Thus, developing antiviral treatments and research in this field has become highly important. Heterocycles, particularly indole motifs, have been a valuable resource in drug discovery, as they can be used as treatments or inspire the synthesis of new potent candidates. Indole-containing drugs, such as enfuvirtide (T-20), arbidol, and delavirdine, have demonstrated significant efficacy in treating viral diseases. This review aims to comprehensively assess the latest research and developments in novel indoles as potential scaffolds for antiviral activity. We have compiled detailed information about indoles as potential antivirals by conducting a thorough literature survey from the past ten years. The review includes discussions on synthetic protocols, inhibitory concentrations, SAR study, and computational study. This review shall identify new antiviral indoles that may help to combat new viral threats in the future.
近年来，COVID-19、寨卡病毒、尼帕病毒、埃博拉病毒、流感、猴痘和登革热等病毒感染对全球健康产生了重大影响。这些疫情促使全球卫生部门采取了更多行动，并加强了合作，以有效应对和减轻这些重大威胁。因此，开发抗病毒治疗方法和相关研究变得至关重要。杂环化合物，特别是吲哚母核，在药物发现中是一种很有价值的资源，因为它们可以作为治疗方法或启发合成新的有效候选药物。含有吲哚的药物，如恩夫韦肽（T-20）、阿比朵尔和依法韦仑，已被证明在治疗病毒病方面具有显著疗效。本综述旨在全面评估新型吲哚作为抗病毒活性的潜在支架的最新研究和进展。我们通过对过去十年的文献进行全面调查，详细收集了吲哚作为潜在抗病毒药物的信息。综述包括合成方案、抑制浓度、SAR 研究和计算研究的讨论。本综述将确定新的抗病毒吲哚，这些药物可能有助于应对未来新的病毒威胁。
