Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, PR China.
State Key Laboratory of Chemical Biology and Drug Discovery, and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, PR China.
Eur J Med Chem. 2025 Jan 5;281:117012. doi: 10.1016/j.ejmech.2024.117012. Epub 2024 Oct 28.
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common multi-resistant organisms found in hospital-acquired infections and is associated with high morbidity and mortality. The development of new drugs and promising therapeutic strategies against MRSA is thus an urgent request. In recent years, some natural products have been demonstrated to show great potential in improving the efficacy of antibiotics to treat various drug-resistant bacteria, particularly MRSA. In this context, we aimed to analyze systematically from the prior arts that investigated the synergy between natural products and antibiotics against MRSA. These findings not only give us a better understanding on the mechanism of actions but also shed light on the bioactive molecular scaffolds identified from diverse natural products. In the present study, we concentratedly reviewed the studies that utilized natural products to enhance the potency of conventional antibiotics against MRSA in the last decade. The timely information reported herein may give meaningful insights into the molecular design of novel and potent antibacterial agents and/or effective therapeutics to combat MRSA for practical applications.
耐甲氧西林金黄色葡萄球菌（MRSA）是医院获得性感染中最常见的多耐药菌之一，与高发病率和死亡率相关。因此，开发针对 MRSA 的新药和有前途的治疗策略是当务之急。近年来，一些天然产物已被证明在提高抗生素治疗各种耐药菌，特别是 MRSA 的疗效方面具有巨大潜力。在这种情况下，我们旨在从研究天然产物与抗生素对 MRSA 的协同作用的现有文献中进行系统分析。这些发现不仅使我们更好地了解作用机制，还揭示了从各种天然产物中鉴定出的生物活性分子支架。在本研究中，我们集中回顾了过去十年中利用天然产物来增强传统抗生素对 MRSA 疗效的研究。本文及时报道的信息可能为新型强效抗菌剂的分子设计以及针对 MRSA 的有效治疗策略提供有意义的见解，以用于实际应用。
