Department of Rheumatology, Xingtai People's Hospital, Xingtai, 054001, Hebei Province, China.
Department of Neurology, Xingtai People's Hospital, Xingtai, 054001, Hebei Province, China.
Sci Rep. 2024 Nov 7;14(1):27112. doi: 10.1038/s41598-024-78582-1.
The relationship between the platelet to albumin ratio (PAR) and the disease activity of early rheumatoid arthritis (ERA) remains to be elucidated. This cross-sectional study included 372 patients with ERA who were hospitalized at Xingtai People's Hospital between January 2022 and January 2024. Multiple linear regression analysis was employed to assess the correlation of PAR with Disease Activity Score 28 (DAS28) using erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), and then generalized additive models were used to explore their relationship. After accounting for confounding variables, a positive correlation was observed between the PAR and DAS28-ESR and DAS28-CRP in ERA patients (β (95% CI): 0.20 (0.08, 0.32) and 0.20 (0.08, 0.33), respectively), and the general trends were consistent from the lowest tertile group (T1) to the highest tertile group (T3). Furthermore, a nonlinear relationship was identified between PAR and both DAS28-ESR and DAS28-CRP. Threshold effect analysis indicated that a value of 13.73 was a significant inflection point. In brief, PAR has a threshold effect on the disease activity of ERA. Increased PAR levels were independently positive associated with DAS28-ESR and DAS28-CRP among ERA patients with PAR < 13.73.
血小板与白蛋白比值（PAR）与早期类风湿关节炎（ERA）的疾病活动之间的关系仍有待阐明。本横断面研究纳入了 2022 年 1 月至 2024 年 1 月期间在邢台市人民医院住院的 372 例 ERA 患者。采用多元线性回归分析评估 PAR 与红细胞沉降率（ESR）和 C 反应蛋白（CRP）的 DAS28 之间的相关性，然后使用广义加性模型探讨它们之间的关系。在排除混杂因素后，发现 ERA 患者的 PAR 与 DAS28-ESR 和 DAS28-CRP 呈正相关（β（95%CI）：0.20（0.08，0.32）和 0.20（0.08，0.33）），且从最低三分位组（T1）到最高三分位组（T3）的总体趋势一致。此外，PAR 与 DAS28-ESR 和 DAS28-CRP 之间存在非线性关系。阈值效应分析表明，13.73 是一个显著的拐点。总之，PAR 对 ERA 的疾病活动具有阈值效应。在 PAR<13.73 的 ERA 患者中，PAR 水平升高与 DAS28-ESR 和 DAS28-CRP 呈独立正相关。
