Wang Baolin, Han Feifei, Ding Peng, Tong Juan, Liu Kaiyong, Yan Shuangqin, Wang Sheng, Chen Guanjun, Wu Xiaoyan, Huang Kun, Geng Menglong, Tao Fangbiao
School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China.
Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China.
Environ Health (Wash). 2024 Jun 14;2(9):651-660. doi: 10.1021/envhealth.4c00032. eCollection 2024 Sep 20.
Antibiotic exposure during pregnancy may affect the neurodevelopment of children, but biomonitoring-based population studies on this class of new pollutants are lacking. We conducted a prospective birth cohort study of 2860 mother-child pairs, measured the urinary concentrations of 41 antibiotics and their two metabolites over three trimesters, and assessed children's autism spectrum disorder (ASD) symptoms at 3 years of age. We examined the associations between prenatal antibiotic exposure and children's ASD symptoms. The least absolute shrinkage and selection operator regression screened for Tetracycline and Ofloxacin as important predictors of ASD symptoms. Modified Poisson regression models revealed that maternal Tetracycline exposure throughout pregnancy increased the risk of ASD symptoms (RR: 1.66, 95% CI: 1.14, 2.40). Maternal Tetracycline exposure during the first (RR: 1.74, 95% CI: 1.13, 2.68) and third trimesters (RR: 1.86, 95% CI: 1.16, 3.00) increased the risk of ASD symptoms in boys, and Ofloxacin exposure during the first trimester (RR: 1.47, 95% CI: 1.07, 2.02) increased the risk of ASD symptoms in girls. No dose-dependent relationships between prenatal antibiotic exposure and ASD symptoms were validated by restricted cubic splines. Prenatal exposure to Tetracycline and Ofloxacin may increase the risk of ASD symptoms in children, and the first and third trimesters might be the key windows.
孕期接触抗生素可能会影响儿童的神经发育，但缺乏基于生物监测的关于这类新污染物的人群研究。我们对2860对母婴进行了一项前瞻性出生队列研究，测量了三个孕期中41种抗生素及其两种代谢物的尿液浓度，并在儿童3岁时评估其自闭症谱系障碍（ASD）症状。我们研究了产前抗生素暴露与儿童ASD症状之间的关联。最小绝对收缩和选择算子回归筛选出四环素和氧氟沙星是ASD症状的重要预测因素。修正泊松回归模型显示，孕期全程接触四环素会增加ASD症状的风险（相对危险度：1.66，95%置信区间：1.14，2.40）。孕早期（相对危险度：1.74，95%置信区间：1.13，2.68）和孕晚期（相对危险度：1.86，95%置信区间：1.16，3.00）接触四环素会增加男孩患ASD症状的风险，而孕早期接触氧氟沙星（相对危险度：1.47，95%置信区间：1.07，2.02）会增加女孩患ASD症状的风险。受限立方样条未验证产前抗生素暴露与ASD症状之间的剂量依赖关系。产前接触四环素和氧氟沙星可能会增加儿童患ASD症状的风险，孕早期和孕晚期可能是关键时期。
