Kamp Astrid L, Yousofzai Washma, Kooistra Hans S, Santarelli Giorgia, van Geijlswijk Ingeborg M
Department Clinical Sciences, Division Internal Medicine of Companion Animals, Utrecht University, Utrecht, The Netherlands.
Department Population Health Sciences, IRAS Veterinary and Comparative Pharmacology Group (One Health Pharma) - Pharmacy, Utrecht University, Utrecht, The Netherlands.
JFMS Open Rep. 2024 Nov 6;10(2):20551169241278408. doi: 10.1177/20551169241278408. eCollection 2024 Jul-Dec.
Acute hepatitis and liver damage are rare adverse effects of clopidogrel in humans. In veterinary medicine, clopidogrel is mainly prescribed in the treatment of feline patients with cardiomyopathies. Little is known regarding the safety and adverse effects of clopidogrel in this group of patients. The limited number of studies scarcely report adverse effects. In this case report, a 6-year-old male castrated crossbred cat with the hypertrophic cardiomyopathy phenotype had signs of acute hepatitis after 5 weeks of clopidogrel treatment.
Evaluation of the case and review of the literature indicate that acute hepatitis might be a potential adverse effect of clopidogrel in feline patients. Therefore, hepatotoxicity should be taken into consideration when a feline patient shows clinical deterioration after the use of clopidogrel.
急性肝炎和肝损伤是氯吡格雷在人类中罕见的不良反应。在兽医学中，氯吡格雷主要用于治疗患有心肌病的猫科动物患者。关于氯吡格雷在这类患者中的安全性和不良反应知之甚少。有限的研究几乎没有报告不良反应。在本病例报告中，一只患有肥厚型心肌病表型的6岁去势杂交雄猫在接受氯吡格雷治疗5周后出现急性肝炎症状。
对该病例的评估和文献回顾表明，急性肝炎可能是氯吡格雷在猫科动物患者中的潜在不良反应。因此，当猫科动物患者在使用氯吡格雷后出现临床恶化时，应考虑肝毒性。
