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喹喔啉衍生物的研究进展：合成路线及对呼吸道病原体的抗病毒疗效

Advances in quinoxaline derivatives: synthetic routes and antiviral efficacy against respiratory pathogens.

作者信息

Dehnavi Fateme, Akhavan Malihe, Bekhradnia Ahmadreza

机构信息

Pharmaceutical Sciences Research Center, Department of Medicinal Chemistry, Mazandaran University of Medical Sciences Sari Iran

出版信息

RSC Adv. 2024 Nov 7;14(48):35400-35423. doi: 10.1039/d4ra04292a. eCollection 2024 Nov 4.

DOI:10.1039/d4ra04292a
PMID:39512644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11542553/
Abstract

The study of quinoxalines as nitrogen-rich heterocyclic compounds has garnered substantial interest within scientific research owing to their multidimensional functionalization capabilities and significant biological activities. The scope of study encompasses their application as potent antiviral agents, particularly within the domain of respiratory pathologies-a topic of pivotal concern in this comprehensive review. They have several prominent pharmacological effects, such as potential influenza inhibitors, potential anti-SARS coronavirus inhibitors, potential anti-SARS-CO-2 coronavirus inhibitors, and miscellaneous respiratory antiviral activities. As a result, some of the literature has described many of these quinoxalines using various synthetic methods for their mentioned biological effects. In the present review, we provided insight into quinoxaline synthesis, structure-activity relationship (SAR), and antiviral activities, along with a compilation of recent studies. The article further encapsulates the gamut of past and ongoing research efforts in the design and synthetic exploration of antiviral scaffolds, with a pronounced emphasis on their strategic deployment against viral pandemics, contextualized against the tapestry of the recent COVID-19 outbreak. This illuminates the quintessential role of quinoxalines in the armamentarium against viral pathogens and provides a platform for the development of next-generation antiviral agents.

摘要

喹喔啉作为富含氮的杂环化合物，因其多维度功能化能力和显著的生物活性，在科学研究中引起了广泛关注。研究范围包括它们作为强效抗病毒剂的应用，特别是在呼吸道疾病领域——这是本综述的核心关注主题。它们具有多种显著的药理作用，如潜在的流感抑制剂、潜在的抗SARS冠状病毒抑制剂、潜在的抗SARS-CoV-2冠状病毒抑制剂以及其他呼吸道抗病毒活性。因此，一些文献描述了许多这些喹喔啉用于上述生物效应的各种合成方法。在本综述中，我们深入探讨了喹喔啉的合成、构效关系（SAR）和抗病毒活性，并汇编了近期研究。本文进一步概括了过去和正在进行的抗病毒支架设计和合成探索的研究工作范围，特别强调了它们针对病毒大流行的战略部署，并结合近期COVID-19疫情背景进行阐述。这阐明了喹喔啉在对抗病毒病原体的武器库中的关键作用，并为下一代抗病毒药物的开发提供了一个平台。

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