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在开放式鼓室成形术中使用冻干同种异体骨进行乳突充填:一种新技术的描述及病例报告

Mastoid Obliteration With Freeze-Dried Bone Allograft in Canal Wall Down Tympanoplasty: Description of a Novel Technique and Case Report.

作者信息

Faita Antonio, Montagner Giulia, Trojan Diletta, Di Pasquale Fiasca Valerio Maria

机构信息

Section of Otorhinolaryngology, Cittadella Hospital, Cittadella, Italy.

Fondazione Banca dei Tessuti del Veneto, Treviso, Italy.

出版信息

Case Rep Surg. 2024 Oct 30;2024:4874411. doi: 10.1155/2024/4874411. eCollection 2024.

DOI:10.1155/2024/4874411
PMID:39512677
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11540884/
Abstract

Mastoid obliteration can be performed after canal wall down (CWD) mastoidectomy with various materials. Homologous bone tissue harvested from cadaver donor represents a feasible option with advantages. The purpose of the study is to describe the case of a patient diagnosed with middle ear cholesteatoma treated with mastoidectomy of the CWD and mastoid obliteration with homologous freeze-dried corticocancellous bone particulate in the Cittadella Hospital Ear, Nose, Throat (ENT) unit. The preoperative characteristics of the patients, the procurement and processing of bone allografts, the surgical technique, and postsurgical outcomes are described. No perioperative and postoperative complications were observed, and no rejection or foreign body reactions occurred. The patient then underwent a seriated follow-up. Audiometric tests showed an improvement in hearing levels. The volume of the neoexternal ear canal was 2.01 cm. The case demonstrated clinical stability, substantial hearing recovery, and no need for specialist cleaning of the reformed external ear canal (EEC). The freeze-dried bone tissue allograft, in the technical way we used, appears to be a viable option in mastoid obliteration because homologous bone is not affected by material shortage, has fast assimilation, and ensures a useful radiological examination scan, at a low cost.

摘要

乳突切除术后可使用多种材料进行乳突填塞。从尸体供体获取的同种异体骨组织是一种可行的选择,具有诸多优点。本研究旨在描述一名被诊断为中耳胆脂瘤的患者,在奇塔代拉医院耳鼻喉科接受完耳道壁下(CWD)乳突切除及使用同种异体冻干皮质松质骨颗粒进行乳突填塞的治疗情况。文中描述了患者的术前特征、骨移植材料的获取与处理、手术技术以及术后结果。未观察到围手术期及术后并发症,也未发生排斥反应或异物反应。随后对该患者进行了系列随访。听力测试显示听力水平有所改善。新外耳道体积为2.01立方厘米。该病例显示出临床稳定性、显著的听力恢复,且无需对重建的外耳道(EEC)进行专业清理。以我们所采用的技术方式,冻干骨组织同种异体移植在乳突填塞中似乎是一种可行的选择,因为同种异体骨不受材料短缺影响,吸收迅速,且能以低成本确保进行有效的放射学检查扫描。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/570a/11540884/c2f4cfb218c1/CRIS2024-4874411.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/570a/11540884/c94be7b84f1b/CRIS2024-4874411.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/570a/11540884/6011fd0e39ca/CRIS2024-4874411.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/570a/11540884/e7ea804c97dc/CRIS2024-4874411.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/570a/11540884/a6ba47a21a8b/CRIS2024-4874411.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/570a/11540884/c2f4cfb218c1/CRIS2024-4874411.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/570a/11540884/c94be7b84f1b/CRIS2024-4874411.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/570a/11540884/6011fd0e39ca/CRIS2024-4874411.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/570a/11540884/e7ea804c97dc/CRIS2024-4874411.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/570a/11540884/a6ba47a21a8b/CRIS2024-4874411.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/570a/11540884/c2f4cfb218c1/CRIS2024-4874411.005.jpg

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本文引用的文献

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Sci Rep. 2023 Oct 20;13(1):17945. doi: 10.1038/s41598-023-44901-1.
2
Use of bonalive in obliterative mastoidectomy: anatomical results and clinical outcome.在阻塞性乳突切除术中使用博来霉素:解剖学结果和临床结果。
Eur Arch Otorhinolaryngol. 2023 Aug;280(8):3577-3583. doi: 10.1007/s00405-023-07850-z. Epub 2023 Mar 14.
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Dorsal Augmentation: A Review of Current Graft Options.背部增强术:当前移植选择综述
Eplasty. 2023 Jan 16;23:e4. eCollection 2023.
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Comparison of Outcomes of Open Mastoid Cavity- with or Without Obliteration.开放乳突腔(有或无填塞)结局的比较。
Indian J Otolaryngol Head Neck Surg. 2022 Dec;74(Suppl 3):4341-4344. doi: 10.1007/s12070-021-03011-y. Epub 2022 Jan 8.
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Mastoid obliteration versus canal wall down or canal wall up mastoidectomy for cholesteatoma: Systematic review and meta-analysis.胆脂瘤的乳突腔闭塞术与开放式或完壁式乳突根治术:系统评价与荟萃分析
Am J Otolaryngol. 2023 Mar-Apr;44(2):103751. doi: 10.1016/j.amjoto.2022.103751. Epub 2022 Dec 27.
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Congenital cholesteatoma clinical and surgical management.先天性胆脂瘤的临床与外科治疗
Int J Pediatr Otorhinolaryngol. 2023 Jan;164:111401. doi: 10.1016/j.ijporl.2022.111401. Epub 2022 Dec 8.
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Cholesteatoma surgery in the pediatric population: remaining challenges in the era of mastoid obliteration.小儿胆脂瘤手术:乳突填塞时代的遗留挑战。
Eur Arch Otorhinolaryngol. 2023 Apr;280(4):1713-1722. doi: 10.1007/s00405-022-07669-0. Epub 2022 Oct 8.
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