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本文引用的文献

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Accumulation of antibiotics in the environment: Have appropriate measures been taken to protect Canadian human and ecological health?抗生素在环境中的积累:是否采取了适当措施来保护加拿大的人类和生态健康?
Ecotoxicol Environ Saf. 2024 Jul 15;280:116513. doi: 10.1016/j.ecoenv.2024.116513. Epub 2024 May 30.
2
Trends, Capacity Growth, and Current State of Community Pharmacies in Saudi Arabia: Findings and Implications of a 16-Year Retrospective Study.沙特阿拉伯社区药房的趋势、容量增长及现状:一项16年回顾性研究的结果与启示
Risk Manag Healthc Policy. 2023 Dec 21;16:2833-2847. doi: 10.2147/RMHP.S443325. eCollection 2023.
3
Participation in the 2022 antibiotic amnesty.
Vet Rec. 2022 Nov;191(9):388. doi: 10.1002/vetr.2419.
4
Factors influencing inappropriate use of antibiotics: Findings from a nationwide survey of the general public in Malaysia.影响抗生素不合理使用的因素:来自马来西亚全国公众调查的结果。
PLoS One. 2021 Oct 20;16(10):e0258698. doi: 10.1371/journal.pone.0258698. eCollection 2021.
5
Lack of Awareness of the Impact of Improperly Disposed Of Medications and Associated Factors: A Cross-Sectional Survey in Indonesian Households.对不当处置药物的影响及相关因素的认知不足:印度尼西亚家庭的横断面调查
Front Pharmacol. 2021 Apr 26;12:630434. doi: 10.3389/fphar.2021.630434. eCollection 2021.
6
National action to combat AMR: a One-Health approach to assess policy priorities in action plans.国家行动打击抗生素耐药性:采用一种“同一健康”方法评估行动计划中的政策重点。
BMJ Glob Health. 2020 Jul;5(7). doi: 10.1136/bmjgh-2020-002427.
7
"Knowledge and practices of HIV infected patients regarding medicine disposal among patients attending public ARV clinics in KwaZulu Natal, South Africa".“南非夸祖鲁-纳塔尔省接受公共抗逆转录病毒治疗诊所治疗的艾滋病毒感染者在处理药物方面的知识和做法”。
BMC Public Health. 2020 Jun 8;20(1):884. doi: 10.1186/s12889-020-09018-4.
8
Cleaning up China's Medical Cabinet-An Antibiotic Take-Back Programme to Reduce Household Antibiotic Storage for Unsupervised Use in Rural China: A Mixed-Methods Feasibility Study.清理中国的药箱——一项减少中国农村家庭抗生素无监管储存以供自行使用的抗生素回收计划:一项混合方法可行性研究
Antibiotics (Basel). 2020 Apr 27;9(5):212. doi: 10.3390/antibiotics9050212.
9
Improper disposal of unused antibiotics: an often overlooked driver of antimicrobial resistance.未使用抗生素的不当处置:一个常被忽视的抗菌药物耐药性驱动因素。
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10
Improving the content validity of the mixed methods appraisal tool: a modified e-Delphi study.提升混合方法评价工具的内容效度:一项改良版的电子德尔菲研究。
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沙特阿拉伯社区药房未使用抗生素的处置:一项混合方法研究。

Disposal of Unused Antibiotics in Community Pharmacies in Saudi Arabia: A Mixed-Methods Study.

作者信息

Aloudah Nouf, Alsaja Raghad Abdulaziz, Bin Mohareb Abeer Mohammed, Alshabanah Aljoharah O, Alammari Raghad Bakr

机构信息

Clinical Pharmacy Department, King Saud University, Riyadh, Saudi Arabia.

College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

出版信息

Integr Pharm Res Pract. 2024 Nov 3;13:201-207. doi: 10.2147/IPRP.S488482. eCollection 2024.

DOI:10.2147/IPRP.S488482
PMID:39512802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11542484/
Abstract

INTRODUCTION

Improper disposal of unused antibiotics poses a significant global challenge, drawing attention from various stakeholders. This discharge of antibiotics into the environment can occur through various means such as industrial production, consumption, and excretion by humans and animals, as well as improper disposal of unused or expired antibiotics. The aim of our study is to investigate the availability of proper disposal of antibiotics in community pharmacies and to explore obstacles and opportunities from pharmacist's point of view.

METHODS

This study used a mixed-methods approach that consisted of two study arms: quantitative and qualitative. The quantitative arm used a mystery-shopper method for assessing the disposal of antibiotics in community pharmacies. The qualitative study arm consisted of several in-depth semi-structured focus groups with a sample of pharmacists working in community pharmacies in Riyadh.

RESULTS

The mystery shopper arm showed that 85% (n=88) refused to take the return of antibiotics. Interviews with pharmacists have indicated a lack of knowledge on safe disposal methods for antibiotics and medications. Additionally, pharmacists have cited several factors contributed to accumulation of the antibiotics such as nonadherence or policies mandating the sale of whole medication packs instead of the required amounts as a contributing factor to this issue. Furthermore, there is a lack of dedicated facilities for the population to safely dispose of their medications and/antibiotics.

CONCLUSION

By acknowledging the factors contributing to improper disposal practices, recognizing the importance of proper antibiotic disposal, and advocating for multi-faceted initiatives, we can work towards mitigating this critical issue. Through collaborative efforts involving education, policy interventions, and community engagement, we can foster a culture of responsible medication disposal, ultimately safeguarding public health and environmental well-being.

摘要

引言

未使用抗生素的不当处置构成了一项重大的全球挑战,引起了各利益相关方的关注。抗生素通过多种途径进入环境,如工业生产、人类和动物的消费与排泄,以及未使用或过期抗生素的不当处置。我们研究的目的是调查社区药房抗生素的妥善处置情况,并从药剂师的角度探索障碍和机遇。

方法

本研究采用混合方法,包括两个研究分支:定量研究和定性研究。定量研究分支采用神秘顾客法评估社区药房抗生素的处置情况。定性研究分支由几个深入的半结构化焦点小组组成,样本为利雅得社区药房工作的药剂师。

结果

神秘顾客研究表明,85%(n = 88)的药房拒绝回收抗生素。对药剂师的访谈表明,他们缺乏抗生素及药品安全处置方法的知识。此外,药剂师列举了导致抗生素积压的几个因素,如不遵守规定或政策要求整包销售药品而非所需剂量,这是造成该问题的一个因素。此外,缺乏供民众安全处置药品和/抗生素的专用设施。

结论

通过认识到导致不当处置行为的因素,认识到妥善处置抗生素的重要性,并倡导多方面举措,我们可以努力缓解这一关键问题。通过教育、政策干预和社区参与等合作努力,我们可以培育一种负责任的药品处置文化,最终保障公众健康和环境福祉。