Department of Periodontics, PMNM Dental College and Hospital, Karnataka, India.
Can J Dent Hyg. 2024 Oct 1;58(3):155-160. eCollection 2024 Oct.
Oncostatin M (OSM), a 28 kDa glycoprotein 130 pleiotropic cytokine belonging to the interleukin-6 (IL-6) family, is mainly produced by neutrophils, activated T cells, monocytes, and macrophages. In response to tissue injury, it may stimulate the production of IL-6 alone or act synergistically with IL-6 or TNF-α contributing to the inflammatory cycle. Periodontitis is an inflammatory disease resulting from a dysbiotic bacterial community, which has a strong association with increased OSM production.
To investigate and compare the levels of salivary and serum OSM in healthy subjects and subjects with periodontitis.
Eighty-eight (88) individuals between the ages of 25 and 60 years were divided into 2 groups of 44: a periodontally healthy group (Group A) and a periodontitis group (Group B) based on clinical examination and radiographic analysis. Evaluation of salivary and serum OSM by enzyme-linked immunosorbent assay (ELISA) was performed in both groups.
There was a significant difference in OSM levels between Groups A and B ( < 0.01), with higher values in Group B. There was a positive correlation between the clinical parameters and OSM levels, indicating that OSM plays a significant role in modulating the inflammatory response of periodontal tissues.
The expression of cytokine OSM may play a potential role in the immunopathogenesis of periodontitis, suggesting a role as an inflammatory diagnostic marker.
孤啡肽（OSM）是一种 28kDa 的糖蛋白，属于白细胞介素-6（IL-6）家族的 130 种细胞因子，主要由中性粒细胞、活化的 T 细胞、单核细胞和巨噬细胞产生。在组织损伤时，它可能单独刺激白细胞介素-6的产生，或与白细胞介素-6或 TNF-α协同作用，有助于炎症循环。牙周炎是一种由细菌群落失调引起的炎症性疾病，与 OSM 产量增加有很强的关联。
调查和比较健康受试者和牙周炎患者的唾液和血清 OSM 水平。
88 名年龄在 25 岁至 60 岁之间的个体根据临床检查和影像学分析分为两组，每组 44 人：牙周健康组（A 组）和牙周炎组（B 组）。通过酶联免疫吸附试验（ELISA）对两组的唾液和血清 OSM 进行评估。
A 组和 B 组之间的 OSM 水平存在显著差异（<0.01），B 组的 OSM 水平更高。临床参数与 OSM 水平之间存在正相关，表明 OSM 在调节牙周组织的炎症反应中发挥着重要作用。
细胞因子 OSM 的表达可能在牙周炎的免疫发病机制中发挥潜在作用，提示其可能作为炎症的诊断标志物。
