Mikami Tsubasa, Kawamura Takuji, Ito Yoshito, Misumi Yusuke, Kashiyama Noriyuki, Kawamura Ai, Kawamura Masashi, Yoshioka Daisuke, Shimamura Kazuo, Toda Koichi, Miyagawa Shigeru
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-2-E1, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Department of Cardiovascular Surgery, Fukui Cardiovascular Center, Fukui, Japan.
Gen Thorac Cardiovasc Surg Cases. 2023 May 29;2(1):61. doi: 10.1186/s44215-023-00070-1.
The use of donor hearts with valvular disease has been considered debatable in heart transplantation for many years. However, few reports indicate successful heart transplantation using donor hearts with mitral regurgitation that underwent mitral valve repair on the back bench.
We report two cases of a 38-year-old and a 48-year-old woman with implantable left ventricular assist devices who underwent heart transplantation at our institution. Transthoracic echocardiography of donor hearts just before the explant revealed that each donor heart had preserved cardiac function and significant mitral regurgitation due to mitral posterior leaflet prolapse and annular dilatation, respectively. Bench mitral valve repair was accomplished using triangular resection for one patient and annuloplasty for the other. This was followed by confirmation of excellent mitral leaflet coaptation without residual mitral regurgitation. Transthoracic echocardiography and right heart catheterization performed 6 months after transplantation clarified the favorable cardiac function of each transplanted heart without mitral regurgitation recurrence.
Efficient utilization of donor hearts with mitral regurgitation may be acceptable when the cardiac function of donor hearts with mitral regurgitation is preserved and heart transplantation, including bench mitral valve repair, is feasible within an acceptable ischemic time.
多年来,在心脏移植中使用患有瓣膜疾病的供体心脏一直存在争议。然而,很少有报告表明使用在体外进行二尖瓣修复的二尖瓣反流供体心脏成功进行心脏移植。
我们报告了两例在我院接受心脏移植的女性患者,分别为38岁和48岁,均植入了左心室辅助装置。在取出供体心脏前进行的经胸超声心动图检查显示,每个供体心脏的心脏功能均得以保留,且分别因二尖瓣后叶脱垂和瓣环扩张导致明显的二尖瓣反流。一名患者采用三角形切除术,另一名患者采用瓣环成形术在体外完成二尖瓣修复。随后证实二尖瓣叶对合良好,无残余二尖瓣反流。移植后6个月进行的经胸超声心动图检查和右心导管检查表明,每个移植心脏的心脏功能良好,无二尖瓣反流复发。
当二尖瓣反流供体心脏的心脏功能得以保留,且在可接受的缺血时间内进行包括体外二尖瓣修复在内的心脏移植可行时,有效利用二尖瓣反流供体心脏可能是可以接受的。