Dorobisz Karolina, Dorobisz Tadeusz, Pazdro-Zastawny Katarzyna, Czyż Katarzyna, Janczak Marzena
Department of Otolaryngology, Head and Neck Surgery, Wrocław Medical University, 50-367 Wroclaw, Poland.
Department of Vascular, General and Transplantation Surgery, Wroclaw Medical University, 50-367 Wroclaw, Poland.
Cancers (Basel). 2024 Nov 1;16(21):3707. doi: 10.3390/cancers16213707.
Radiotherapy is an effective method of treating cancer and affects 50% of patients. Intensity-modulated radiotherapy (IMRT) is a modernized method of classical radiation used in the treatment of laryngeal cancer. Treatment with intent to preserve the larynx is not always safe or complication-free. The microbiome may significantly influence the effectiveness of oncological treatment, especially radiotherapy, and may also be modified by the toxic response to radiation.
The aim of the study was to prospectively assess the microbiome and its influence on radiotherapy toxicity in patients with laryngeal cancer.
Statistically significant risk factors for complications after radiotherapy were the percentage of Porphyromonas of at least 6.7%, the percentage of Fusobacterium of at least 2.6% and the percentage of Catonella of at least 2.6%.
The importance of the microbiome in oncology has been confirmed in many studies. Effective radiotherapy treatment and the prevention of radiation-induced oral mucositis is a challenge in oncology. The microbiome may be an important part of personalized cancer treatment. The assessment of the microbiome of patients diagnosed with cancer may provide the opportunity to predict the response to treatment and its effectiveness. The influence of the microbiome may be important in predicting the risk group for radiotherapy treatment failure. The possibility of modifying the microbiome may become a goal to improve the prognosis of patients with laryngeal cancer. Fusobacterium, Porphyromonas and Catonella are important risk factors for radiation-induced oral mucositis in patients with laryngeal cancer.
放射治疗是治疗癌症的一种有效方法，50%的患者会接受该治疗。调强放射治疗（IMRT）是用于喉癌治疗的经典放射疗法的现代化方法。旨在保留喉部的治疗并不总是安全或无并发症的。微生物群可能会显著影响肿瘤治疗的效果，尤其是放射治疗，并且也可能会因对辐射的毒性反应而发生改变。
本研究的目的是前瞻性评估喉癌患者的微生物群及其对放射治疗毒性的影响。
放射治疗后发生并发症的统计学显著风险因素是卟啉单胞菌属占比至少6.7%、梭杆菌属占比至少2.6%以及卡顿氏菌属占比至少2.6%。
微生物群在肿瘤学中的重要性已在许多研究中得到证实。有效的放射治疗以及预防放射性口腔黏膜炎是肿瘤学中的一项挑战。微生物群可能是个性化癌症治疗的重要组成部分。对癌症患者微生物群的评估可能提供预测治疗反应及其效果的机会。微生物群的影响在预测放射治疗失败的风险组方面可能很重要。改变微生物群的可能性可能成为改善喉癌患者预后的一个目标。梭杆菌属、卟啉单胞菌属和卡顿氏菌属是喉癌患者放射性口腔黏膜炎的重要风险因素。
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