免疫组织化学标志物在判定腐败尸体损伤存活情况中的应用：一项小型文献综述
Immunohistochemical markers in the determination of lesion viability in decomposed bodies: A mini literature review.
作者信息
Salzillo Cecilia, Innamorato Liliana, Leggio Alessia, Marzullo Andrea
机构信息
Department of Experimental Medicine, PhD Course in Public Health, University of Campania "Luigi Vanvitelli", Luciano Armanni 5, Naples 81100, Italy; Department of Precision and Regenerative Medicine and Ionian Area, Pathology Unit, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, Bari 70121, Italy.
S.S.D. Forensic Medicine and Clinical Risk, Santissima Annunziata Central Hospital, Bruno 1, Taranto 74121, Italy.
出版信息
Forensic Sci Int. 2024 Dec;365:112289. doi: 10.1016/j.forsciint.2024.112289. Epub 2024 Nov 5.
The ability to distinguish between viable and post-mortem lesions is crucial in forensic medicine, especially in cases of advanced decomposition. Glycophorin A (GPA) is one of the most studied immunohistochemical markers for assessing lesion viability, with persistence in putrefied tissues up to 6 months. However, its sensitivity decreases beyond 15 days. Other markers such as tryptase, IL-15, CD15, CD45 and matrix metalloproteinases have been tested in decomposition contexts, but the results are inconclusive. This mini review article explores the main studies on immunohistochemical markers, discussing their utility and limitations in forensic investigations of decomposed bodies.
区分生前损伤和死后损伤的能力在法医学中至关重要，尤其是在高度腐败的案件中。血型糖蛋白A（GPA）是评估损伤存活性研究最多的免疫组化标志物之一，在腐败组织中可持续存在长达6个月。然而，超过15天后其敏感性会降低。其他标志物如类胰蛋白酶、白细胞介素-15、CD15、CD45和基质金属蛋白酶已在腐败情况下进行了测试，但结果尚无定论。这篇小型综述文章探讨了关于免疫组化标志物的主要研究，讨论了它们在腐败尸体法医调查中的实用性和局限性。
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