Wu Guan-Lin, Yen Chin-En, Hsu Wei-Chien, Yeh Ming-Long
Department of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan.
Department of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan; Department of Orthopedics, An Nan Hospital, China Medical University, Tainan, Taiwan.
Acta Biomater. 2025 Jan 1;191:80-97. doi: 10.1016/j.actbio.2024.11.008. Epub 2024 Nov 8.
Biodegradable metals offer significant advantages by reducing the need for additional surgeries following bone fixation. These materials, with their optimal mechanical and degradable properties, also mitigate stress-shielding effects while promoting biological processes essential for healing. This study investigated the in vitro and in vivo biocompatibility of ZK60 magnesium alloy coated with a micro-arc oxidative layer incorporated with cerium oxide nanoparticles in orthopedic implants. The results demonstrated that the magnesium substrate undergoes gradual degradation, effectively eliminating long-term inflammation during bone formation. The micro-arc oxidative coating forms a dense ceramic layer, acting as a protective barrier that reduces corrosion rates and enhances the biocompatibility of the magnesium substrate. The incorporation of cerium oxide nanoparticles improves the tribological properties of the coating, refining degradation patterns and improving osteogenic characteristics. Furthermore, cerium oxide nanoparticles enhance bone reconstruction by facilitating appropriate interconnections between newly formed bone and native bone tissue. Consequently, cerium oxide nanoparticles contribute to favorable biosafety outcomes and exceptional bone remodeling capabilities by supporting bone healing and sustaining a prolonged degradation process, ultimately achieving dynamic equilibrium in bone formation. STATEMENT OF SIGNIFICANCE: This study comprehensively examined the incorporation of cerium oxide nanoparticles into biodegradable magnesium through a micro-arc oxidative process for use in orthopedic implants. This study conducted a comprehensive analysis involving material characterization, biodegradability testing, in vitro osteogenesis assays, and in vivo implantation, highlighting the potential benefits of the distinctive properties of cerium oxide nanoparticles. This research emphasizes the ability of cerium oxide nanoparticles to enhance the biodegradability of magnesium and facilitate remarkable bone regeneration, suggesting promising advantages for additive materials in orthopedic implants.
可生物降解金属通过减少骨固定后额外手术的需求而具有显著优势。这些材料具有最佳的机械性能和可降解性能，还能减轻应力屏蔽效应，同时促进愈合所必需的生物过程。本研究调查了在骨科植入物中涂覆有掺有氧化铈纳米颗粒的微弧氧化层的ZK60镁合金的体外和体内生物相容性。结果表明，镁基体逐渐降解，有效消除了骨形成过程中的长期炎症。微弧氧化涂层形成致密的陶瓷层，作为保护屏障降低腐蚀速率并提高镁基体的生物相容性。氧化铈纳米颗粒的掺入改善了涂层的摩擦学性能，细化了降解模式并改善了成骨特性。此外，氧化铈纳米颗粒通过促进新形成的骨与天然骨组织之间的适当连接来增强骨重建。因此，氧化铈纳米颗粒通过支持骨愈合和维持长期降解过程，有助于实现良好的生物安全结果和卓越的骨重塑能力，最终在骨形成中实现动态平衡。意义声明：本研究全面研究了通过微弧氧化工艺将氧化铈纳米颗粒掺入可生物降解镁中用于骨科植入物的情况。本研究进行了全面分析，包括材料表征、生物降解性测试、体外成骨试验和体内植入，突出了氧化铈纳米颗粒独特性能的潜在益处。本研究强调了氧化铈纳米颗粒增强镁的生物降解性并促进显著骨再生的能力，表明其在骨科植入物添加剂材料方面具有潜在优势。
