Center for Cognition and Brain Disorders, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, PR China; Department of radiology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, PR China; School of Biomedical Engineering, ShanghaiTech University, Shanghai, PR China.
Center for Cognition and Brain Disorders, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, PR China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang, PR China.
Neuroimage. 2024 Dec 1;303:120920. doi: 10.1016/j.neuroimage.2024.120920. Epub 2024 Nov 8.
Resting-state functional magnetic resonance imaging (rs-fMRI) is a prominent tool for investigating functional deficits in stroke patients. However, the extent to which the hemodynamic lags (LAG) and the intrinsic cerebrovascular reactivity (iCVR) may affect the rs-fMRI metrics in different scales needs to be clarified for ischemic stroke. In this study, 73 ischemic stroke patients and 74 healthy controls (HC) were recruited to investigate how the correction of the LAG and/or iCVR would influence resting-state functional magnetic resonance imaging (rs-fMRI) metrics of three different spatial scales (local-scale, meso-scale and global-scale) in ischemic stroke. The analysis revealed that the Stroke pattern of all functional metrics using different correction strategies resembled the HC pattern. The highest overlap was observed in the Stroke pattern with correction for both LAG and iCVR, while the pattern without correction showed the lowest overlap. Most functional metrics after correction showed higher sensitivity in detecting between-group differences than those without correction. Moreover, our results were generally reproducible in an independent dataset. Collectively, these findings emphasize the necessity of considering LAG and iCVR effects to investigate stroke-related functional alterations, and highlight the significance of correction strategies for accurately interpreting the findings in rs-fMRI study of ischemic stroke.
静息态功能磁共振成像(rs-fMRI)是研究中风患者功能障碍的重要工具。然而，对于缺血性中风，需要明确血液动力学滞后(LAG)和固有脑血管反应性(iCVR)在不同尺度上对 rs-fMRI 指标的影响程度。在这项研究中，我们招募了 73 名缺血性中风患者和 74 名健康对照者(HC)，以研究校正 LAG 和/或 iCVR 如何影响缺血性中风三种不同空间尺度(局部尺度、中尺度和全局尺度)的静息态功能磁共振成像(rs-fMRI)指标。分析结果表明，使用不同校正策略的所有功能指标的中风模式都类似于 HC 模式。在同时校正 LAG 和 iCVR 的情况下，中风模式的重叠程度最高，而未校正的模式的重叠程度最低。校正后的大多数功能指标在检测组间差异方面的敏感性高于未校正的指标。此外，我们的结果在一个独立的数据集上具有较好的可重复性。综上所述，这些发现强调了在研究中风相关功能改变时，有必要考虑 LAG 和 iCVR 的影响，并突出了校正策略在解释缺血性中风 rs-fMRI 研究中发现的重要性。
