Department of Ophthalmology, Haydarpasa Numune Training and Research Hospital, University of Health Sciences, Tibbiye Street. Nu: 23, 34668, Istanbul, Uskudar, Turkey.
North American Lasik and Eye Surgery Center, 272 Al Wasl Rd, Jumeirah 1, Dubai, United Arab Emirates.
Int Ophthalmol. 2024 Nov 9;44(1):420. doi: 10.1007/s10792-024-03349-6.
We aimed to evaluate the morphological changes in meibomian glands in keratoconus patients using scleral contact lenses and compare them with keratoconus and healthy controls.
The study included 34 eyes of 20 patients who were wearing scleral contact lenses due to keratoconus, as well as 31 age- and sex-matched keratoconus controls and 31 healthy controls. Slit-lamp biomicroscopy, non-invasive tear film break-up time assessment, Schirmer I test, meibography, and corneal staining with fluorescein were performed. Subjective symptoms were assessed using the Ocular Surface Disease Index.
In this study, the lower and upper percentage meibomian gland loss was statistically higher in the scleral contact lens group than in the keratoconus and healthy control groups (p < 0.001 and p = 0.013, respectively). There was a positive correlation between scleral contact lens wear duration and the lower eyelid percentage meibomian gland loss and upper eyelid gland curling scores (rho: 0.396; p = 0.021 and rho: 0.344; p = 0.047, respectively). The lower and upper eyelid percentage meibomian gland loss, and upper eyelid gland curling values were higher, and the Schirmer 1 values were found to be lower in patients who used scleral contact lenses for more than three years than those who wore them less than three years.
In patients using scleral contact lenses for more than three years, meibomian gland curling values and percentages of meibomian gland loss in both eyelids are higher.
我们旨在通过巩膜接触镜评估圆锥角膜患者的睑板腺形态变化，并将其与圆锥角膜和健康对照组进行比较。
本研究纳入了 20 名因圆锥角膜而佩戴巩膜接触镜的患者的 34 只眼，以及 31 名年龄和性别相匹配的圆锥角膜对照组和 31 名健康对照组。进行了裂隙灯生物显微镜检查、非侵入性泪膜破裂时间评估、Schirmer I 试验、睑板腺照相和荧光素角膜染色。使用眼表面疾病指数评估主观症状。
在这项研究中，巩膜接触镜组的下睑和上睑睑板腺缺失百分比明显高于圆锥角膜组和健康对照组（p<0.001 和 p=0.013）。巩膜接触镜佩戴时间与下眼睑睑板腺缺失百分比和上眼睑腺体卷曲评分呈正相关（rho：0.396；p=0.021 和 rho：0.344；p=0.047）。使用巩膜接触镜超过 3 年的患者的下眼睑和上眼睑睑板腺缺失百分比、上眼睑腺体卷曲值更高，而 Schirmer 1 值更低。
对于使用巩膜接触镜超过 3 年的患者，上下眼睑的睑板腺卷曲值和睑板腺缺失百分比均较高。
